CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002908
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-dependent Clp protease ATP-binding subunit ClpX 
Protein Synonyms/Alias
  
Gene Name
 clpX 
Gene Synonyms/Alias
 lopC; b0438; JW0428 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
97VAVYNHYKRLRNGDTacetylation[1]
168IIQKLLQKCDYDVQKacetylation[1]
188VYIDEIDKISRKSDNacetylation[1]
256GAFAGLDKVISHRVEacetylation[1]
280TVKAKSDKASEGELLacetylation[1]
408SVIDGQSKPLLIYGKacetylation[1]
415KPLLIYGKPEAQQASacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. It may bind to the lambda O substrate protein and present it to the ClpP protease in a form that can be recognized and readily hydrolyzed by ClpP. Can perform chaperone functions in the absence of ClpP. 
Sequence Annotation
 ZN_FING 15 40 C4-type.
 NP_BIND 119 126 ATP (Potential).  
Keyword
 3D-structure; ATP-binding; Chaperone; Complete proteome; Direct protein sequencing; Metal-binding; Nucleotide-binding; Reference proteome; Stress response; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 424 AA 
Protein Sequence
MTDKRKDGSG KLLYCSFCGK SQHEVRKLIA GPSVYICDEC VDLCNDIIRE EIKEVAPHRE 60
RSALPTPHEI RNHLDDYVIG QEQAKKVLAV AVYNHYKRLR NGDTSNGVEL GKSNILLIGP 120
TGSGKTLLAE TLARLLDVPF TMADATTLTE AGYVGEDVEN IIQKLLQKCD YDVQKAQRGI 180
VYIDEIDKIS RKSDNPSITR DVSGEGVQQA LLKLIEGTVA AVPPQGGRKH PQQEFLQVDT 240
SKILFICGGA FAGLDKVISH RVETGSGIGF GATVKAKSDK ASEGELLAQV EPEDLIKFGL 300
IPEFIGRLPV VATLNELSEE ALIQILKEPK NALTKQYQAL FNLEGVDLEF RDEALDAIAK 360
KAMARKTGAR GLRSIVEAAL LDTMYDLPSM EDVEKVVIDE SVIDGQSKPL LIYGKPEAQQ 420
ASGE 424 
Gene Ontology
 GO:0005524; F:ATP binding; IDA:EcoCyc.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006457; P:protein folding; IEA:HAMAP.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR013093; ATPase_AAA-2.
 IPR019489; Clp_ATPase_C.
 IPR004487; Clp_protease_ATP-bd_su_ClpX.
 IPR027417; P-loop_NTPase.
 IPR010603; Znf_CppX_C4. 
Pfam
 PF07724; AAA_2
 PF10431; ClpB_D2-small
 PF06689; zf-C4_ClpX 
SMART
 SM00382; AAA
 SM01086; ClpB_D2-small
 SM00994; zf-C4_ClpX 
PROSITE
  
PRINTS