Tag | Content |
---|
CPLM ID | CPLM-043401 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Obscurin |
Protein Synonyms/Alias | |
Gene Name | OBSCN |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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8915 | KRRALLYKRHNLAQV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | |
Sequence Annotation | |
Keyword | ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 8923 AA |
Protein Sequence | MDQPQFSGAP RFLTRPKAFV VSVGKDATLS CQIVGNPTPQ VSWEKDQQPV AAGARFRLAQ 60 DGDLYRLTIL DLALGDSGQY VCRARNAIGE AFAAVGLQVD AEAACAEQAP HFLLRPTSIR 120 VREGSEATFR CRVGGSPRPA VSWSKDGRRL GEPDGPRVRV EELGEASALR IRAARPRDGG 180 TYEVRAENPL GAASAAAALV VDSDAADTAS RPGTSTAALL AHLQRRREAM RAEGAPASPP 240 STGTRTCTVT EGKHARLSCY VTGEPKPETV WKKDGQLVTE GRRHVVYEDA QENFVLKILF 300 CKQSDRGLYT CTASNLVGQT YSSVLVVVRE PAVPFKKRLQ DLEVREKESA TFLCEVPQPS 360 TEAAWFKEET RLWASAKYGI EEEGTERRLT VRNVSADDDA VYICETPEGS RTVAELAVQG 420 NLLRKLPRKT AVRVGDTAMF CVELAVPVGP VHWLRNQEEV VAGGRVAISA EGTRHTLTIS 480 QCCLEDVGQV AFMAGDCQTS TQFCVSAPRK PPLQPPVDPV VKARMESSVI LSWSPPPHGE 540 RPVTIDGYLV EKKKLGTYTW IRCHEAEWVA TPELTVADVA EEGNFQFRVS ALNSFGQSPY 600 LEFPGTVHLA PKLAVRTPLK AVQAVEGGEV TFSVDLTVAS AGEWFLDGQA LKASSVYEIH 660 CDRTRHTLTI REVPASLHGA QLKFVANGIE SSIRMEVRAA PGLTANKPPA AAAREVLARL 720 HEEAQLLAEL SDQAAAVTWL KDGRTLSPGP KYEVQASAGR RVLLVRDVAR DDAGLYECVS 780 RGGRIAYQLS VQGLARFLHK DMAGSCVDAV AGGPAQFECE TSEAHVHVHW YKDGMELGHS 840 GERFLQEDVG TRHRLVAATV TRQDEGTYSC RVGEDSVDFR LRVSEPKAVF AKEQPACREV 900 QAEVGASATL SCEVAQDQME VTWYKDGKKL SSSSKVHVEA VGCMRRLVVQ QVGQADSGEY 960 SCEARGQRVS FRLDVAEPKV VFAKEQLARR KLQAEAGASA TLSCEVAQAQ TEVTWYKDGK 1020 KLSSSSKVCM EATGCTRRLV VQQAGQADAG EYSCEAGGQR LSFHLDVKEP KVVFAKDQVA 1080 HSEVQAEAGA SATLSCEVAQ AQTEVMWYKD GKKLSSSLKV HVEAKGCRRR LVVQQAGKTD 1140 AGDYSCEARG QRVSFRLHIT EPKMMFAKEQ SVHNEVQAEA GASAMLSCEV AQAQTEVTWY 1200 KDGKKLSSSS KVGMEVKGCT RRLVLPQAGK ADAGEYSCEA GGQRVSFHLH ITEPKGVFAK 1260 EQSVHNEVQA EAGTTAMLSC EVAQPQTEVT WYKDGKKLSS SSKVRMEVKG CTRRLVVQQV 1320 GKADAGEYSC EAGGQRVSFQ LHITEPKAVF AKEQLVHNEV RTEAGASATL SCEVAQAQTE 1380 VTWYKDGKKL SSSSKVRIEA AGCMRQLVVQ QAGQADAGEY TCEAGGQRLS FHLDVSEPKA 1440 VFAKEQLAHR KVQAEAGAIA TLSCEVAQAQ TEVTWYKDGK KLSSSSKVRM EAVGCTRRLV 1500 VQQACQADTG EYSCEAGGQR LSFSLDVAEP KVVFAKEQPV HREVQAQAGA STTLSCEVAQ 1560 AQTEVMWYKD GKKLSFSSKV RMEAVGCTRR LVVQQAGQAV AGEYSCEAGS QRLSFHLHVA 1620 EPKAVFAKEQ PAHREVQAEA GASATLSCEV AQAQTEVTWY KDGKKLSSSL KVHVEAAGCT 1680 RRLVVQQAGQ ADTGEYSCEA GGQQLSFRLQ VAEPKAVFAK EQPASREVQA EAGTSATLSC 1740 EVAQAQTEVT WYKDGKKLSS SSKVRMEAVG CTRRLVVQEA GQADAGEYSC KAGDQRLSFH 1800 LHVAEPKVVF AKEQPAHREV QAEAGASATL SCEVAQAQTE VTWYKDGKKL SSSSKVRVEA 1860 VGCTRRLVVQ QAGQAEAGEY SCEAGGQQLS FRLQVAEPKA VFAKEQVVFA KDQPVHREVQ 1920 AEAGTSTMLS CEVAQAQTEV MWYKDGKKLS SSSKMRVEAV GCTRRLVVQE AGQADAGEYS 1980 CEAGGQRLSF HLHVAEPKVV FAKEQPACRE VQAEAGASAT LSCEVAQGQM EVTWYKDGKK 2040 LSSSSKVHME ASGYTRRLVV QQAGQADAGE YSCEAGGQRL SFRLHVAELE PQISERPCRR 2100 EPLVVKEHED IILTATLATP SAATVTWLKD GVEIRRSKRH ETASQGDTHT LTVHGAQVLD 2160 SAIYSCRVGA EGQDFPVQVE EVAAKFCRLL EPVCGELGGT VTLACELSPA CAEVVWRCGN 2220 TQLRVGKRFQ MVAEGPVRSL TVLGLRAEDA GEYVCESRDD HTSAQLTVSV PRVVKFMSGL 2280 STVVAEEGGE ATFQCVVSPS DVAVVWFRDG ALLQPSEKFA ISQSGASHSL TISDLVLEDA 2340 GQITVEAEGA SSSAALRVRE APVLFKKKLE PQTVEERSSV TLEVELTRPW PELRWTRNAT 2400 ALAPGKNVEI HAEGARHRLV LHNVGFADRG FFGCETPDDK TQAKLTVEMR QVRLVRGLQA 2460 VEAREQGTAT MEVQLSHADV DGSWTRDGLR FQQGPTCHLA VRGPMHTLTL SGLRPEDSGL 2520 MVFKAEGVHT SARLVVTELP VSFSRPLQDV VTTEKEKVTL ECELSRPNVD VRWLKDGVEL 2580 RAGKTMAIAA QGACRSLTIY RCEFADQGVY VCDAHDAQSS ASVKVQGRNI QIVRPLEDVE 2640 VMEKDGATFS CEVSHDEVPG QWFWEGSKLR PTDNVRIRQE GRTYTLIYRR VLAEDAGEIQ 2700 FVAENAESRA QLRVKELPVT LVRPLRDKIA MEKHRGVLEC QVSRASAQVR WFKGSQELQP 2760 GPKYELVSDG LYRKLIISDV HAEDEDTYTC DAGDVKTSAQ FFVEEQSITI VRGLQDVTVM 2820 EPAPAWFECE TSIPSVRPPK WLLGKTVLQA GGNVGLEQEG TVHRLMLRRT CSTMTGPVHF 2880 TVGKSRSSAR LVVSDIPVVL TRPLEPKTGR ELQSVVLSCD FRPAPKAVQW YKDDTPLSPS 2940 EKFKMSLEGQ MAELRILRLM PADAGVYRCQ AGSAHSSTEV TVEAREVTVT GPLQDAEATE 3000 EGWASFSCEL SHEDEEVEWS LNGMPLYNDS FHEISHKGRR HTLVLKSIQR ADAGIVRASS 3060 LKVSTSARLE VRVKPVVFLK ALDDLSAEER GTLALQCEVS DPEAHVVWRK DGVQLGPSDK 3120 YDFLHTAGTR GLVVHDVSPE DAGLYTCHVG SEETRARVRV HDLHVGITKR LKTMEVLEGE 3180 SCSFECVLSH ESASDPAMWT VGGKTVGSSS RFQATRQGRK YILVVREAAP SDAGEVVFSV 3240 RGLTSKASLI VRERPAAIIK PLEDQWVAPG EDVELRCELS RAGTPVHWLK DRKAIRKSQK 3300 YDVVCEGTMA MLVIRGASLK DAGEYTCEVE ASKSTASLHV EEKANCFTEE LTNLQVEEKG 3360 TAVFTCKTEH PAATVTWRKG LLELRASGKH QPSQEGLTLR LTISALEKAD SDTYTCDIGQ 3420 AQSRAQLLVQ GRRVHIIEDL EDVDVQEGSS ATFRCRISPA NYEPVHWFLD KTPLHANELN 3480 EIDAQPGGYH VLTLRQLALK DSGTIYFEAG DQRASAALRV TEKPSVFSRE LTDATITEGE 3540 DLTLVCETST CDIPVCWTKD GKTLRGSARC QLSHEGHRAQ LLITGATLQD SGRYKCEAGG 3600 ACSSSIVRVH ARPVRFQEAL KDLEVLEGGA ATLRCVLSSV AAPVKWCYGN NVLRPGDKYS 3660 LRQEGAMLEL VVRNLRPQDS GRYSCSFGDQ TTSATLTVTA LPAQFIGKLR NKEATEGATA 3720 TLRCELSKAA PVEWRKGSET LRDGDRYCLR QDGAMCELQI RGLAMVDAAE YSCVCGEERT 3780 SASLTIRPMP AHFIGRLRHQ ESIEGATATL RCELSKAAPV EWRKGRESLR DGDRHSLRQD 3840 GAVCELQICG LAVADAGEYS CVCGEERTSA TLTVKALPAK FTEGLRNEEA VEGATAMLWC 3900 ELSKVAPVEW RKGPENLRDG DRYILRQEGT RCELQICGLA MADAGEYLCV CGQERTSATL 3960 TIRALPARFI EDVKNQEARE GATAVLQCEL NSAAPVEWRK GSETLRDGDR YSLRQDGTKC 4020 ELQIRGLAMA DTGEYSCVCG QERTSAMLTV RALPIKFTEG LRNEEATEGA TAVLRCELSK 4080 MAPVEWWKGH ETLRDGDRHS LRQDGARCEL QIRGLVAEDA GEYLCMCGKE RTSAMLTVRA 4140 MPSKFIEGLR NEEATEGDTA TLWCELSKAA PVEWRKGHET LRDGDRHSLR QDGSRCELQI 4200 RGLAVVDAGE YSCVCGQERT SATLTVRALP ARFIEDVKNQ EAREGATAVL QCELSKAAPV 4260 EWRKGSETLR GGDRYSLRQD GTRCELQIHG LSVADTGEYS CVCGQERTSA TLTVRALPAR 4320 FTQDLKTKEA SEGATATLQC ELSKVAPVEW KKGPETLRDG GRYSLKQDGT RCELQIHDLS 4380 VADAGEYSCM CGQERTSATL TVRALPARFT EGLRNEEAME GATATLQCEL SKAAPVEWRK 4440 GLEALRDGDK YSLRQDGAVC ELQIHGLAMA DNGVYSCVCG QERTSATLTV RALPARFIED 4500 MRNQKATEGA TVTLQCKLRK AAPVEWRKGP NTLKDGDRYS LKQDGTSCEL QIRGLVIADA 4560 GEYSCICEQE RTSATLTVRA LPARFIEDVR NHEATEGATA VLQCELSKAA PVEWRKGSET 4620 LRDGDRYSLR QDGTRCELQI RGLAVEDTGE YLCVCGQERT SATLTVRALP ARFIDNMTNQ 4680 EAREGATATL HCELSKVAPV EWRKGPETLR DGDRHSLRQD GTRCELQIRG LSVADAGEYS 4740 CVCGQERTSA TLTIRALPAK FTKGLRNEEA TEGATAMLQC ELSKVAPVEW RKGPETLRDG 4800 DRYNLRQDGT RCELQIHGLS VADTGEYSCV CGQEKTSATL TVKAPQPVFR EPLQSLQAEE 4860 GSTATLQCEL SEPTATVVWS KGGLQLQANG RREPRLQGCT AELVLQDLQR EDTGEYTCTC 4920 GSQATSATLT VTAAPVRFLR ELQHQEVDEG GTAHLCCELS RAGASVEWRK GSLQLFPCAK 4980 YQMVQDGAAA ELLVRGVEQE DAGDYTCDTG HTQSMASLSV RVPRPKFKTR LQSLEQETGD 5040 IARLCCQLSD AESGAVVQWL KEGVELHAGP KYEMRSQGAT RELLIHQLEA KDTGEYACVT 5100 GGQKTAASLR VTEPEVTIVR GLVDAEVTAD EDVEFSCEVS RAGATGVQWC LQGLPLQSNE 5160 VTEVAVRDGR IHTLRLKGVT PEDAGTVSFH LGNHASSAQL TVRAPEVTIL EPLQDVQLSE 5220 GQDASFQCRL SRASGQEARW ALGGVPLQAN EMNDITVEQG TLHLLTLHKV TLEDAGTVSF 5280 HVGTCSSEAQ LKVTAKNTVV RGLENVEALE GGEALFECQL SQPEVAAHTW LLDDEPVHTS 5340 ENAEVVFFEN GLRHLLLLKN LRPQDSCRVT FLAGDMVTSA FLTVRGWRLE ILEPLKNAAV 5400 RAGAQACFTC TLSEAVPVGE ASWYINGAAV QPDDSDWTVT ADGSHHALLL RSAQPHHAGE 5460 VTFACRDAVA SARLTVLGLP DPPEDAEVVA RSSHTVTLSW AAPMSDGGGG LCGYRVEVKE 5520 GATGQWRLCH ELVPGPECVV DGLAPGETYR FRVAAVGPVG AGEPVHLPQT VRLAEPPKPV 5580 PPQPSAPESR QVAAGEDVSL ELEVVAEAGE VIWHKGMERI QPGGRFEVVS QGRQQMLVIK 5640 GFTAEDQGEY HCGLAQGSIC PAAATFQVAL SPASVDEAPQ PSLPPEAAQE GDLHLLWEAL 5700 ARKRRMSREP TLDSISELPE EDGRSQRLPQ EAEEVAPDLS EGYSTADELA RTGDADLSHT 5760 SSDDESRAGT PSLVTYLKKA GRPGTSPLAS KVGAPAAPSV KPQQQQEPLA AVRPPLGDLS 5820 TKDLGDPSMD KAAVKIQAAF KGYKVRKEMK QQEGPMFSHT FGDTEAQVGD ALRLECVVAS 5880 KADVRARWLK DGVELTDGRH HHIDQLGDGT CSLLITGLDR ADAGCYTCQV SNKFGQVTHS 5940 ACVVVSGSES EAESSSGGEL DDAFRRAARR LHRLFRTKSP AEVSDEELFL SADEGPAEPE 6000 EPADWQTYRE DEHFICIRFE ALTEARQAVT RFQEMFATLG IGVEIKLVEQ GPRRVEMCIS 6060 KETPAPVVPP EPLPSLLTSD AAPVFLTELQ NQEVQDGYPV SFDCVVTGQP MPSVRWFKDG 6120 KLLEEDDHYM INEDQQGGHQ LIITAVVPAD MGVYRCLAEN SMGVSSTKAE LRVDLTSTDY 6180 DTAADATESS SYFSAQGYLS SREQEGTEST TDEGQLPQVV EELRDLQVAP GTRLAKFQLK 6240 VKGYPAPRLY WFKDGQPLTA SAHIRMTDKK ILHTLEIISV TREDSGQYAA YISNAMGAAY 6300 SSARLLVRGP DEPEEKPASD VHEQLVPPRM LERFTPKKVK KGSSITFSVK VEGRPVPTVH 6360 WLREEAERGV LWIGPDTPGY TVASSAQQHS LVLLDVGRQH QGTYTCIASN AAGQALCSAS 6420 LHVSGLPKVE EQEKVKEALI STFLQGTTQA ISAQGLETAS FADLGGQRKE EPLAAKEALG 6480 HLSLAEVGTE EFLQKLTSQI TEMVSAKITQ AKLQVPGGDS DEDSKTPSAS PRHGRSRPSS 6540 SIQESSSESE DGDARGEIFD IYVVTADYLP LGAEQDAITL REGQYVEVLD AAHPLRWLVR 6600 TKPTKSSPSR QGWVSPAYLD RRLKLSPEWG AAEAPEFPGE AVSEDEYKAR LSSVIQELLS 6660 SEQAFVEELQ FLQSHHLQHL ERCPHVPIAV AGQKAVIFRN VRDIGRFHSS FLQELQQCDT 6720 DDDVAMCFIK NQAAFEQYLE FLVGRVQAES VVVSTAIQEF YKKYAEEALL AGDPSQPPPP 6780 PLQHYLEQPV ERVQRYQALL KELIRNKARN RQNCALLEQA YAVVSALPQR AENKLHVSLM 6840 ENYPGTLQAL GEPIRQGHFI VWEGAPGARM PWKGHNRHVF LFRNHLVICK PRRDSRTDTV 6900 SYVFRNMMKL SSIDLNDQVE GDDRAFEVWQ EREDSVRKYL LQARTAIIKS SWVKEICGIQ 6960 QRLALPVWRP PDFEEELADC TAELGETVKL ACRVTGTPKP VISWYKDGKA VQVDPHHILI 7020 EDPDGSCALI LDSLTGVDSG QYMCFAASAA GNCSTLGKIL VQVPPRFVNK VRASPFVEGE 7080 DAQFTCTIEG APYPQIRWYK DGALLTTGNK FQTLSEPRSG LLVLVIRAAS KEDLGLYECE 7140 LVNRLGSARA SAELRIQSPM LQAQEQCHRE QLVAAVEDTT LERADQEVTS VLKRLLGPKA 7200 PGPSTGDLTG PGPCPRGAPA LQETGSQPPV TGTSEAPAVP PRVPQPLLHE GPEQEPEAIA 7260 RAQEWTVPIR MEGAAWPGAG TGELLWDVHS HVVRETTQRT YTYQAIDTHT ARPPSMQVTI 7320 EDVQAQTGGT AQFEAIIEGD PQPSVTWYKD SVQLVDSTRL SQQQEGTTYS LVLRHVASKD 7380 AGVYTCLAQN TGGQVLCKAE LLVLGGDNEP DSEKQSHRRK LHSFYEVKEE IGRGVFGFVK 7440 RVQHKGNKIL CAAKFIPLRS RTRAQAYRER DILAALSHPL VTGLLDQFET RKTLILILEL 7500 CSSEELLDRL YRKGVVTEAE VKVYIQQLVE GLHYLHSHGV LHLDIKPSNI LMVHPAREDI 7560 KICDFGFAQN ITPAELQFSQ YGSPEFVSPE IIQQNPVSEA SDIWAMGVIS YLSLTCSSPF 7620 AGESDRATLL NVLEGRVSWS SPMAAHLSED AKDFIKATLQ RAPQARPSAA QCLSHPWFLK 7680 SMPAEEAHFI NTKQLKFLLA RSRWQRSLMS YKSILVMRSI PELLRGPPDS PSLGVARHLC 7740 RDTGGSSSSS SSSDNELAPF ARAKSLPPSP VTHSPLLHPR GFLRPSASLP EEAEASERST 7800 EAPAPPASPE GAGPPAAQGC VPRHSVIRSL FYHQAGESPE HGALAPGSRR HPARRRHLLK 7860 GGYIAGALPG LREPLMEHRV LEEEAAREEQ ATLLAKAPSF ETALRLPASG THLAPGHSHS 7920 LEHDSPSTPR PSSEACGEAQ RLPSAPSGGA PIRDMGHPQG SKQLPSTGGH PGTAQPERPS 7980 PDSPWGQPAP FCHPKQGSAP QEGCSPHPAV APCPPGSFPP GSCKEAPLVP SSPFLGQPQA 8040 PPAPAKASPP LDSKMGPGDI SLPGRPKPGP CSSPGSASQA SSSQVSSLRV GSSQVGTEPG 8100 PSLDAEGWTQ EAEDLSDSTP TLQRPQEQAT MRKFSLGGRG GYAGVAGYGT FAFGGDAGGM 8160 LGQGPMWARI AWAVSQSEEE EQEEARAESQ SEEQQEARAE SPLPQVSARP VPEVGRAPTR 8220 SSPEPTPWED IGQVSLVQIR DLSGDAEAAD TISLDISEVD PAYLNLSDLY DIKYLPFEFM 8280 IFRKVPKSAQ PEPPSPMAEE ELAEFPEPTW PWPGELGPHA GLEITEESED VDALLAEAAV 8340 GRKRKWSSPS RSLFHFPGRH LPLDEPAELG LRERVKASVE HISRILKGRP EGLEKEGPPR 8400 KKPGLASFRL SGLKSWDRAP TFLRELSDET VVLGQSVTLA CQVSAQPAAQ ATWSKDGAPL 8460 ESSSRVLISA TLKNFQLLTI LVVVAEDLGV YTCSVSNALG TVTTTGVLRK AERPSSSPCP 8520 DIGEVYADGV LLVWKPVESY GPVTYIVQCS LEGGSWTTLA SDIFDCCYLT SKLSRGGTYT 8580 FRTACVSKAG MGPYSSPSEQ VLLGGPSHLA SEEESQGRSA QPLPSTKTFA FQTQIQRGRF 8640 SVVRQCWEKA SGRALAAKII PYHPKDKTAV LREYEALKGL RHPHLAQLHA AYLSPRHLVL 8700 ILELCSGPEL LPCLAERASY SESEVKDYLW QMLSATQYLH NQHILHLDLR SENMIITEYN 8760 LLKVVDLGNA QSLSQEKVLP SDKFKDYLET MELLEGQGAV PQTDIWAIGV TAFIMLSAEY 8820 PVSSEGARDL QRGLRKGLVR LSRCYAGLSG GAVAFLRSTL CAQPWGRPCA SSCLQCPWLT 8880 EEGPACSRPA PVTFPTARLR VFVRNREKRR ALLYKRHNLA QVR 8923 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |