CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022707
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquilin-2 
Protein Synonyms/Alias
 Chap1; DSK2 homolog; Protein linking IAP with cytoskeleton 2; PLIC-2; Ubiquitin-like product Chap1/Dsk2 
Gene Name
 Ubqln2 
Gene Synonyms/Alias
 Plic2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
31ASPPAEPKIIKVTVKubiquitination[1]
41KVTVKTPKEKEEFAVubiquitination[1]
43TVKTPKEKEEFAVPEacetylation[2]
43TVKTPKEKEEFAVPEubiquitination[1]
58NSTVQQFKEAISKRFubiquitination[1]
66EAISKRFKSQTDQLVubiquitination[1]
79LVLIFAGKILKDQDTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation (By similarity). Links CD47 to vimentin- containing intermediate filaments of the cytoskeleton. 
Sequence Annotation
 DOMAIN 33 107 Ubiquitin-like.
 REPEAT 505 507 1.
 REPEAT 508 510 2.
 REPEAT 511 513 3.
 REPEAT 514 516 4.
 REPEAT 517 519 5.
 REPEAT 520 522 6.
 REPEAT 523 525 7.
 REPEAT 526 528 8.
 REPEAT 529 531 9.
 REPEAT 532 533 10.
 REPEAT 535 537 11.
 DOMAIN 589 635 UBA.
 REGION 505 537 11 X 3 AA tandem repeats P-X-X.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 25 25 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 638 AA 
Protein Sequence
MAENGESSGP PRPSRGPAAA PGAASPPAEP KIIKVTVKTP KEKEEFAVPE NSTVQQFKEA 60
ISKRFKSQTD QLVLIFAGKI LKDQDTLMQH GIHDGLTVHL VIKSQNRPQG QATTQPSTTA 120
GTSTTTTTTT TAAAPAATTS SAPRSSSTPT TTNSSSFGLG SLSSLSNLGL NSPNFTELQN 180
QMQQQLLASP EMMIQIMENP FVQSMLSNPD LMRQLIMANP QMQQLIQRNP EISHLLNNPD 240
IMRQTLEIAR NPAMMQEMMR NQDLALSNLE SIPGGYNALR RMYTDIQEPM LNAAQEQFGG 300
NPFATVGSSS TSGEGTQPSR TENRDPLPNP WAPPPTTQTA ATTTTTTTTS SGSGSGSSSS 360
STTAGNTMAA ANYVASIFST PGMQSLLQQI TENPQLIQNM LSAPYMRSMM QSLSQNPDMA 420
AQMMLSSPLF TSNPQLQEQM RPQLPNFLQQ MQNPETIAAM SNPRAMQALM QIQQGLQTLA 480
TEAPGLIPSF APGVGMGVLG TAITPVGPVT PIGPIGPIVP FTPIGPIGPI GPTGPASSPG 540
STGTGIPPAT TVSSSAPTET ISPTSESGPN QQFIQQMVQA LTGGSPPQPP NPEVRFQQQL 600
EQLNAMGFLN REANLQALIA TGGDINAAIE RLLGSQPS 638 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara. 
Interpro
 IPR016024; ARM-type_fold.
 IPR006636; STI1_HS-bd.
 IPR009060; UBA-like.
 IPR000449; UBA/transl_elong_EF1B_N.
 IPR015940; UBA/transl_elong_EF1B_N_euk.
 IPR015496; Ubiquilin.
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 
Pfam
 PF00627; UBA
 PF00240; ubiquitin 
SMART
 SM00727; STI1
 SM00165; UBA
 SM00213; UBQ 
PROSITE
 PS50030; UBA
 PS00299; UBIQUITIN_1
 PS50053; UBIQUITIN_2 
PRINTS