UniProt Accession

 RS3_DROME; Q06559; Q9VCM9 

Genbank Protein ID

 L13690; X72921; AE014297; AY118971 

Genbank Nucleotide ID

 AAA28875.1; CAA51425.1; AAF56129.1; AAM50831.1 

Protein Name

 40S ribosomal protein S3 

Protein Synonyms/Alias

  

Gene Name

 RpS3 

Gene Synonyms/Alias

 M(3)95A; CG6779 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
64	TQQVLGEKGRRIREL	acetylation	[1]
92	RIELYAEKVAARGLC	acetylation	[1]
197	VMLPYDPKNKIGPKK	acetylation	[1]
219	VVEPKEEKIYETPET	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Has DNA repair activity directed towards the mutagenic lesions 8-oxoguanine and abasic sites in DNA. It can cleave DNA containing 8-oxoguanine residues efficiently. Also acts as an ap lyase, cleaving phosphodiester bonds via a beta,delta elimination reaction. 

Sequence Annotation

 DOMAIN 23 94 KH type-2.
 MOD_RES 223 223 Phosphothreonine.
 MOD_RES 226 226 Phosphothreonine.
 MOD_RES 241 241 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0016363; C:nuclear matrix; IDA:FlyBase.
 GO:0005840; C:ribosome; IDA:FlyBase.
 GO:0015935; C:small ribosomal subunit; IEA:InterPro.
 GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
 GO:0008534; F:oxidized purine nucleobase lesion DNA N-glycosylase activity; IDA:FlyBase.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; IDA:FlyBase.
 GO:0006281; P:DNA repair; IGI:FlyBase.
 GO:0007067; P:mitosis; IMP:FlyBase.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:FlyBase.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0006412; P:translation; IEA:InterPro. 

Interpro

 IPR004087; KH_dom.
 IPR015946; KH_dom-like_a/b.
 IPR004044; KH_dom_type_2.
 IPR009019; KH_prok-type.
 IPR001351; Ribosomal_S3_C.
 IPR018280; Ribosomal_S3_CS.
 IPR005703; Ribosomal_S3_euk/arc. 

Pfam

 PF07650; KH_2
 PF00189; Ribosomal_S3_C 

SMART

 SM00322; KH 

PROSITE

 PS50823; KH_TYPE_2
 PS00548; RIBOSOMAL_S3 

PRINTS