CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027366
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isocitrate dehydrogenase [NADP] 
Protein Synonyms/Alias
  
Gene Name
 PF13_0242 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
69PYVNLKIKYFDLSIEacetylation[1]
180LKIEKSGKFEIVFTPacetylation[1]
245STKSTILKIYDGLFKacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
 NP_BIND 104 106 NADP (By similarity).
 NP_BIND 338 343 NADP (By similarity).
 REGION 123 129 Substrate binding (By similarity).
 METAL 280 280 Magnesium or manganese (By similarity).
 METAL 303 303 Magnesium or manganese (By similarity).
 BINDING 106 106 Substrate (By similarity).
 BINDING 111 111 NADP (By similarity).
 BINDING 138 138 Substrate (By similarity).
 BINDING 161 161 Substrate (By similarity).
 BINDING 288 288 NADP (By similarity).
 BINDING 356 356 NADP; via amide nitrogen and carbonyl  
Keyword
 Complete proteome; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Reference proteome; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 468 AA 
Protein Sequence
MGKHIRILKN QYLQFMSKRC IQSKAAFNIC GKINVENPIV ELDGDEMTRI IWKDIKEKLI 60
LPYVNLKIKY FDLSIENRDK TNDQVTIEAA EEIKKTSVGI KCATITPDAA RVKEFNLKEM 120
WKSPNGTIRN ILDGTVFRTP ILIKNIPKLV PNWKKPIVIG RHAYADQYKQ KSLKIEKSGK 180
FEIVFTPDDN SQVLRETVFH FKSPGVCLGM YNTEESIRNF ALSCFQYALD LKMPVYMSTK 240
STILKIYDGL FKDIFDEIYE KQFKKSFEQH NLWYEHKLID DMVAQVLKSE GGFLWACKNY 300
DGDIQSDAVA QGYGSLGLMS SVLLCPDGVT CVSEAAHGTV TRHYRAYQKG EKTSTNPIAS 360
IFAWTKGLEH RAKLDKNDNL KQFCYALEKA CIETVEDGLM SKDLAGCIKG IKNVTEKDYI 420
FTQDLINAIN EKLKLKILQN QSKNDPQATS YKLKNDNWNF YAPQEHST 468 
Gene Ontology
 GO:0005739; C:mitochondrion; ISS:GeneDB_Pfalciparum.
 GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006102; P:isocitrate metabolic process; ISS:GeneDB_Pfalciparum.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW. 
Interpro
 IPR019818; IsoCit/isopropylmalate_DH_CS.
 IPR004790; Isocitrate_DH_NADP.
 IPR024084; IsoPropMal-DH-like_dom. 
Pfam
 PF00180; Iso_dh 
SMART
  
PROSITE
 PS00470; IDH_IMDH 
PRINTS