| Tag | Content |
|---|
| CPLM ID | CPLM-021866 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dual specificity protein phosphatase 14 |
Protein Synonyms/Alias | Mitogen-activated protein kinase phosphatase 6; MAP kinase phosphatase 6; MKP-6 |
Gene Name | Dusp14 |
Gene Synonyms/Alias | Mkp6 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 187 | IIPDVYEKESRHLMP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. |
Sequence Annotation | DOMAIN 91 156 Tyrosine-protein phosphatase.
ACT_SITE 111 111 Phosphocysteine intermediate (By |
Keyword | Complete proteome; Hydrolase; Protein phosphatase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 198 AA |
Protein Sequence | MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRAS VASNWHLLQA RGITCVINAT 60
IEIPNFNWPQ FEYVKVPLAD IPHAPIRLYF DTVADKIHSV SKKHGATLVH CAAGVSRSAT 120
LCIAYLMKFH NLCLLEAYNW VKARRPVIRP NLGFWRQLID YESQLFGKSS VKMVQTPYGI 180
IPDVYEKESR HLMPYWGI 198 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:MGI. GO:0005634; C:nucleus; ISS:MGI. GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IEA:InterPro. GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IBA:RefGenome. GO:0035335; P:peptidyl-tyrosine dephosphorylation; IBA:RefGenome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |