| Tag | Content |
|---|
| CPLM ID | CPLM-016065 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | WD repeat domain phosphoinositide-interacting protein 2 |
Protein Synonyms/Alias | WIPI-2 |
Gene Name | Wipi2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 198 | AFDASGTKLATASEK | ubiquitination | [1] | | 323 | CSLTTIQKIPRLLVG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P (By similarity). |
Sequence Annotation | REPEAT 182 222 WD 1.
REPEAT 228 267 WD 2.
REPEAT 311 349 WD 3.
MOD_RES 394 394 Phosphoserine.
MOD_RES 395 395 Phosphoserine. |
Keyword | Autophagy; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 445 AA |
Protein Sequence | MNLASQSGEA GAGQLLFANF NQDNTSLAVG SKSGYKFFSL SSVDKLEQIY ECTDTEDVCI 60
VERLFSSSLV AIVSLKAPRK LKVCHFKKGT EICNYSYSNT ILAVKLNRQR LIVCLEESLY 120
IHNIRDMKVL HTIRETPPNP AGLCALSINN DNCYLAYPGS ASIGEVQVFD TINLRAANMI 180
PAHDSPLAAL AFDASGTKLA TASEKGTVIR VFSIPEGQKL FEFRRGVKRC VSICSLAFSM 240
DGMFLSASSN TETVHIFKLE AVREKPPEEP TTWTGYFGKV LMASTSYLPS QVTEMFNQGR 300
AFATVRLPFC GHKNICSLTT IQKIPRLLVG ASDGYLYMYN LDPQEGGECA LMRQHRLDGS 360
METTSEIVDS ASHDCPLATQ TYGTAAAKGA YVPSSPTRLG KGQDANLEAY TDDLGAVGGA 420
CLEDEASALR LDEDSEHPPM ILRTD 445 |
Gene Ontology | GO:0000421; C:autophagic vacuole membrane; IBA:RefGenome. GO:0005829; C:cytosol; ISS:UniProtKB. GO:0005634; C:nucleus; IEA:Compara. GO:0034045; C:pre-autophagosomal structure membrane; ISS:UniProtKB. GO:0043234; C:protein complex; IEA:Compara. GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; ISS:UniProtKB. GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB. GO:0000045; P:autophagic vacuole assembly; ISS:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |