UniProt Accession

 CRIP1_HUMAN; P50238; H3BPI2; Q13628; Q53XY7; Q96J34 

Genbank Protein ID

 U09770; U58630; BT007181; AL928654; BC002738 

Genbank Nucleotide ID

 AAA64537.1; AAB61158.1; AAP35845.1; AAH02738.1 

Protein Name

 Cysteine-rich protein 1 

Protein Synonyms/Alias

 CRP-1; Cysteine-rich heart protein; CRHP; hCRHP; Cysteine-rich intestinal protein; CRIP 

Gene Name

 CRIP1 

Gene Synonyms/Alias

 CRIP; CRP1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
9	PKCPKCNKEVYFAER	acetylation	[1, 2]
9	PKCPKCNKEVYFAER	ubiquitination	[3, 4]
22	ERVTSLGKDWHRPCL	acetylation	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. 

Sequence Annotation

 DOMAIN 2 63 LIM zinc-binding.
 MOD_RES 9 9 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 77 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0003680; F:AT DNA binding; IDA:UniProtKB.
 GO:0008301; F:DNA binding, bending; IDA:UniProtKB.
 GO:0042277; F:peptide binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; TAS:UniProtKB.
 GO:0071236; P:cellular response to antibiotic; IDA:UniProtKB.
 GO:0071493; P:cellular response to UV-B; IDA:UniProtKB.
 GO:0007507; P:heart development; TAS:UniProtKB.
 GO:0006955; P:immune response; IEP:UniProtKB.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IDA:UniProtKB.
 GO:0060741; P:prostate gland stromal morphogenesis; IEP:UniProtKB.
 GO:0010468; P:regulation of gene expression; IEP:UniProtKB.
 GO:0010033; P:response to organic substance; IEP:UniProtKB.
 GO:0010043; P:response to zinc ion; IDA:UniProtKB. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS