CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024185
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inositol 1,4,5-trisphosphate receptor type 2 
Protein Synonyms/Alias
 IP3 receptor isoform 2; IP3R 2; InsP3R2; Inositol 1,4,5-trisphosphate type V receptor; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptor 
Gene Name
 Itpr2 
Gene Synonyms/Alias
 Itpr5 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
909SYFERLSKFQDGSNNubiquitination[1]
1565QVNTLFMKNHSSTVQubiquitination[1]
1589ARSGPRFKEALGGPAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. 
Sequence Annotation
 DOMAIN 112 166 MIR 1.
 DOMAIN 173 223 MIR 2.
 DOMAIN 231 287 MIR 3.
 DOMAIN 294 372 MIR 4.
 DOMAIN 378 434 MIR 5.
 REGION 265 269 Inositol 1,4,5-trisphosphate binding (By
 REGION 507 510 Inositol 1,4,5-trisphosphate binding (By
 REGION 567 569 Inositol 1,4,5-trisphosphate binding (By
 MOD_RES 937 937 Phosphoserine; by PKA.
 MOD_RES 1160 1160 Phosphoserine (By similarity).
 MOD_RES 1709 1709 Phosphoserine.
 MOD_RES 2607 2607 Phosphotyrosine (Potential).  
Keyword
 Alternative splicing; Calcium; Calcium channel; Calcium transport; Complete proteome; Endoplasmic reticulum; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2701 AA 
Protein Sequence
MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP KKFRDCLFKV 60
CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENRKL LGEIVKYSNV 120
IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD 180
KVVLMPVNAG QPLHASNVEL LDNPGCKEVN AVNCNTSWKI TLFMKFSSYR EDVLKGGDVV 240
RLFHAEQEKF LTCDDYEKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN 300
SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVKDGEIPTP KKKRQAGEKI MYTLVSVPHG 360
NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS TTIPIDTEEE RPVMLKIGTC 420
QTKEDKEAFA IVCVPLSEVR DLDFANDANK VLATTVKKLE NGSITQNERR FVTKLLEDLI 480
FFVADVTNNG QDVLDVVITK PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED 540
LGDQRYAPYK YVLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH 600
NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NSTAIPVTQE LICKFMLSPG 660
NADILIQTKL VSMQVENPME SSILPDDIDD EEVWLYWIDS NKEPHGKAIR HLAQEAREGT 720
KADLEVLTYY RYQLNLFARM CLDRQYLAIN QISTQLSVDL ILRCVSDESL PFDLRASFCR 780
LMLHMHVDRD PQESVVPVRY ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE 840
YLKEVVNQPF PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM 900
SSYFERLSKF QDGSNNVMRT IHGVGEMMTQ MVLSRGSIFP VSVPDAQPIV HPSKQASPGE 960
QEDVTVMDTK LKVIEILQFI LSVRLDYRIS YMLSIYKKEF GDNNDNGDPS ASGTPDTLLP 1020
SALVPDIDEI AAQAETMFAG RKEKTPVQLD DEGGRTFLRV LIHLIMHDYA PLLSGALQLL 1080
FKHFSQRAEV LQAFKQVQLL VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSGSYENGD 1140
VGEGQAKGGE EANEESNLLS PVQDGAKTPQ IDSNKGNNYR IVKEILIRLS KLCVQNKKCR 1200
NQHQRLLKNM GAHSVVLDLL QIPYEKTDEK MNEVMDLAHT FLQNFCRGNP QNQVLLHKHL 1260
NLFLTPGLLE AETMRHIFMN NYHLCNEISE RVVQHFVHCI ETHGRHVEYL RFLQTIVKAD 1320
GKYVKKCQDM VMTELINGGE DVLIFYNDRA SFPILLNMMC SERARGDESG PLAYHITLVE 1380
LLAACTEGKN VYTEIKCNSL LPLDDIVRVV THDDCIPEVK IAYVNFVNHC YVDTEVEMKE 1440
IYTSNHIWKL FENFLVDMAR VCNTTTDRKH ADTFLERCVT ESVMNIVSGF FNSPFSDNST 1500
SLQTHQPVFI QLLQSAFRIY NCTWPNPAQK ASVESCIRAL AEVAKNRGIA IPVDLDSQVN 1560
TLFMKNHSST VQRAAMGWRL SARSGPRFKE ALGGPAWDYR NIIEKLQDVV ASLEQQFSPM 1620
MQAEFSVLVD VLYSPELLFP EGSDARIRCG AFMSKLINHT KKLMEKEEKL CIKILQTLRE 1680
MLEKKDSFME EGSTLRRILL NRYFKGDHSI SVNGPLSGAY AKTAQVGGSF SGQDSDKKGI 1740
SMSDIQCLLD KEGASELVID VIVNTKNDRI FSEGILLGIA LLEGGNTQTQ YSFYQQLHEQ 1800
KKSEKFFKVL YDRMKAAQKE IRSTVTVNTI DLGSKKREED SDVMALGPRM RVRDSSLHLR 1860
EGMKGQLTEA SSATSKAYCV YRREMDPEID TMCPGQEAGS AEEKSAEEVT MSPAITIMRP 1920
ILRFLQLLCE NHNRELQNFL RNQNNKTNYN LVCETLQFLD CICGSTTGGL GLLGLYINER 1980
NVALVNQTLE SLTEYCQGPC HENQTCIATH ESNGIDIIIA LILNDINPLG KYRMDLVLQL 2040
KNNASKLLLA IMESRHDSEN AERILFNMRP RELVDVMKNA YNQGLECDHG DEEGGDDGVS 2100
PKDVGHNIYI LAHQLARHNK LLQQMLKPGS DPEEGDEALK YYANHTAQIE IVRHDRTMEQ 2160
IVFPVPNICE FLTRESKYRV FNTTERDEQG SKVNDFFQQT EDLYNEMKWQ KKIRNNPALF 2220
WFSRHISLWG SISFNLAVFI NLAVALFYPF GDDGDEGTLS PMFSVLLWVA VAICTSMLFF 2280
FSKPVGIRPF LVSVMLRSIY TIGLGPTLIL LGAANLCNKI VFLVSFVGNR GTFTRGYRAV 2340
ILDMAFLYHV AYVLVCMLGL FVHEFFYSFL LFDLVYREET LLNVIKSVTR NGRSIILTAV 2400
LALILVYLFS IIGFLFLKDD FTMEVDRLKN RTPVTGNHGV PTMTLSSMME TCQKENCSPT 2460
IPSSNTAGEE GEDGIERTCD TLLMCIVTVL NQGLRNGGGV GDVLRRPSKD EPLFAARVVY 2520
DLLFFFIVII IVLNLIFGVI IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVSFE 2580
EHIKSEHNMW HYLYFIVLVK VKDPTEYTGP ESYVAQMITE KNLDWFPRMR AMSLVSNEGD 2640
SEQNEIRNLQ EKLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN TPHVNHHMPP 2700
H 2701 
Gene Ontology
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0016529; C:sarcoplasmic reticulum; IDA:MGI.
 GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Compara.
 GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IDA:MGI.
 GO:0035091; F:phosphatidylinositol binding; IDA:MGI.
 GO:0071320; P:cellular response to cAMP; IDA:UniProtKB.
 GO:0071361; P:cellular response to ethanol; IMP:MGI.
 GO:0001666; P:response to hypoxia; IEA:Compara. 
Interpro
 IPR000699; Ca-rel_channel.
 IPR014821; Ins145_P3_rcpt.
 IPR000493; InsP3_rcpt-bd.
 IPR005821; Ion_trans_dom.
 IPR016093; MIR_motif.
 IPR013662; RIH_assoc-dom.
 IPR015925; Ryanodine_recept-rel. 
Pfam
 PF08709; Ins145_P3_rec
 PF00520; Ion_trans
 PF02815; MIR
 PF08454; RIH_assoc
 PF01365; RYDR_ITPR 
SMART
 SM00472; MIR 
PROSITE
 PS50919; MIR 
PRINTS
 PR00779; INSP3RECEPTR.