| Tag | Content |
|---|
| CPLM ID | CPLM-015681 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | F-box only protein 22 |
Protein Synonyms/Alias | |
Gene Name | Fbxo22 |
Gene Synonyms/Alias | Fbx22 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 196 | FHFIKDSKNLTLERH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. |
Sequence Annotation | DOMAIN 18 70 F-box.
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 193 193 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 402 AA |
Protein Sequence | MEPAGGGGGV SSSTDPRSTY VLSNLAEVVE RVFTFLPAKA LLRVAGVCRL WRECVRRVLR 60
THRSVTWISA GVAEAGHLEG HCLVRVVAEA LENVRILPQT VLYMADSETF ISLEECRGHK 120
RARKRTTMET ACALEKLFPK QCQVLGIVTP GIVVTPMGSG SNRPQEIEIG ESGFALLFPQ 180
IEGIKIQPFH FIKDSKNLTL ERHQLTEVGL LDNPELRVVL VFGYNCCKVG ASNYLHRVVS 240
TFSDMNIILA GGQVDNLSSL TCEKNPLDID ATGVVGLSFS GHRIQSATVL LTEDVNDAKT 300
VEAAMQRLKA ANIPEQNTIG FMFACVGRGF QYYRAKGNVE ADAFRKFFPS VPLFGFFGNG 360
EIGCDRIVTG NFILRRCNEV KEEDLFHSYT TIMALVHLGT SK 402 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:MGI. GO:0005634; C:nucleus; IDA:MGI. GO:0030018; C:Z disc; IEA:UniProtKB-SubCell. GO:0009267; P:cellular response to starvation; IDA:MGI. GO:0006913; P:nucleocytoplasmic transport; IDA:MGI. GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI. GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:MGI. GO:0000209; P:protein polyubiquitination; IDA:MGI. GO:0010830; P:regulation of myotube differentiation; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |