CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024772
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein furry homolog 
Protein Synonyms/Alias
  
Gene Name
 Fry 
Gene Synonyms/Alias
 Kiaa4143 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1821TPKNQNSKSAEQLSNubiquitination[1]
1878FQIFRALKQPLSAHAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. 
Sequence Annotation
 MOD_RES 213 213 Phosphotyrosine (By similarity).
 MOD_RES 1936 1936 Phosphoserine (By similarity).
 MOD_RES 2516 2516 Phosphothreonine; by CDK1.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3020 AA 
Protein Sequence
MASQQDSGFF EISIKYLLKS WSNASPVGNG YIKPPVPPAS GTHREKGPPA MLPINVDPDS 60
KPGEYVLKSL FVNFTTQAER KIRIIMAEPL EKPLTKSLQR GEDPQFDQVI SSMSSLSEYC 120
LPSILRTLFD WYKRQNGIED ESHEYRPRTS NKSKSDEQQR DYLMERRDLA IDFIFSLVLI 180
EVLKQIPLHP VIDSLIHDII NLAFKHFKYK EGYLGPNTGN MHIVADLYAE VIGVLAQAKF 240
PAVKKKFMAE LKELRHKEQS PYVVQSIISL IMGMKFFRIK MYPVEDFEAS LQFMQECAHY 300
FLEVKDKDIK HALAGLFVEI LVPVAAAVKN EVNVPCLRNF VESLYDTTLE LSSRKKHSLA 360
LYPLVTCLLC VSQKQLFLNR WHVFLNNCLS NLKNKDPKMA RVALESLYRL LWVYMIRIKC 420
ESNTATQSRL ITITTTLFPK GSRGVVPRDM PLNIFVKIIQ FIAQERLDFA MKEIIFDFLC 480
VGKPAKAFSL NPERMNIGLR AFLVIADSLQ QKDGEPPMPV TGAVLPSGNT LRVKKTYLSK 540
TLTEEEAKMI GMSLYYSQVR KAVGNILRHL DKEVGRCMML TNVQMLNKEP EDMITGERKP 600
KIDLFRTCVA AIPRLLPDGM SKLELIDLLA RLSIHMDDEL RHIAQNSLQG LLVDFSDWRE 660
DVLFGFTNFL LREVNDMHHT LLDSSLKLLL QLLTQWKLVI QTQGRAYEQA NKIRNSELIP 720
NGSSHRMQSE RGPHCSVLHA VEGFALVLLC SFQVATRKLS VLILKEIRAL FLALGQPEDD 780
DRPMIDVMDQ LSSSILESFI HVAVSDSATL PPTHNVDLQW LVEWNAVLVN SHYDVKSPSH 840
VWIFAQSVKD PWVLCLFSFL RQENLPKHCP TALSYAWPYA FTRLQSVMPL VDPNSPVNAK 900
KTSTASSGDN YVTLWRNYLI LCFGVAKPSI MSPGHLRAST PEIMATTPDG TVSYDNKAIG 960
TPSVGVLLKQ LVPLMRLESI EITESLVLGF GRTNSLVFRE LVEELHPLMK EALERRPENK 1020
KRRERRDLLR LQLLRIFELL ADAGVISDST NGALERDTLA LGALFLEYVD LTRMLLEAEN 1080
DKEVEILKDI RAHFSAMVAN LIQCVPVHHR RFLFPQQSLR HHLFILFSQW AGPFSIMFTP 1140
LDRYSDRNHQ ITRYQYCALK AMSAVLCCGP VFDNVGLSPD GYLYKWLDNI LACQDLRVHQ 1200
LGCEVVMLLL ELNPDQINLF NWAIDRCYTG SYQLASGCFK AIATVCGNRN YPFDIVTLLN 1260
LVLFKASDTN REIYEVSMQL MQILEAKLFV HSKKVAEQRP GSILYGTHGP LPPLYSVSLA 1320
LLSCELARMY PELTLPLFSE VSQRFPTTHP NGRQIMLTYL LPWLHNIELV DSRLLLPGSS 1380
PSSPEDEVKD REGEVTASHG LKGNGWGSPE ATSLVLNNLM YMTAKYGDEV PGAEMENAWN 1440
ALANNEKWSN NLRVTLQFLI SLCGVSSDTI LLPYIKKVAT YLCRNNTIQT MEELLFELQQ 1500
TEPVNPIVQH CDNPPFYRFT ASSKASAAAS GTTSSSNTVV AGQDSFPDPE ESKILKESDD 1560
RFSNVIRAHT RLESRYSNSS GGSYDEDKND PISPYTGWLL SITEAKQPQP LPMPCSGGCW 1620
APLVDYLPET ITPRGPLHRC NIAVIFMTEM VVDHSVREDW ALHLPLLLHA VFLGLDHYRP 1680
EVFEHSKKLL LHLLIALSCN SNFHAIASVL LQTREMGEAK TLTMQPAYQP EYLYTGGFDF 1740
LREDQSSPVP DSGLNSSSTS SSISLGGSSG NLPQMTQEVE DVEAATETDE KASKLIEFLT 1800
TRAFGPLWCH EDITPKNQNS KSAEQLSNFL RHVVSVFKDS RSGFHLEQHL SEVALQTALA 1860
SSSRHYAGRS FQIFRALKQP LSAHALSDLL SRLVEVIGEH GDEIQGYVME ALLTLEAAVD 1920
NLSDCLKNSD LFTVLSRSSS PDLSSSSKLT ASRKSTGQLN VNPGTPGSGG GGGGSGNTTT 1980
AERSRHQRSF SVPKKFGVVD RSSDPPRSAT LDRIQACTQQ GLSSKTRSNS SLKESLTDPS 2040
HVSHPTNLLA TIFWVTVALM ESDFEFEYLM ALRLLNRLLA HMPLEKAENR EKLEKLQAQL 2100
KWADFPGLQQ LLLKGFTSLT TTDLTLQLFS LLTSVSKVPM VDSSQAIGFP LNVLCLLPQL 2160
IQHFENPNQF CKDIAERIAQ VCLEEKNPKL SNLAHVMTLY KTHSYTRDCA TWVNVVCRYL 2220
HEAYADITLN MVTYLAELLE KGLPSMQQPL LQVIYSLLSY MDLSVVPVKQ FNMEVLKTIE 2280
KYVQSIHWRE ALNILKLVVS RSASLVLPSY QHSDLSKIEL HRVWTSASKE LPGKTLDFHF 2340
DISETPIIGR RYDELQNSSG RDGKPRAMAV TRSASSTSSG SNSNVLVPVS WKRPQYSQKR 2400
TKEKLVHVLS LCGQEVGLSK NPSVIFSSCG DLDLPEHQTS LVSSEDGPRE QENMDDTNSE 2460
QQFRVFRDFD FLDVELEDGE GESMDNFNWG VRRRSLDSLD KCDMQILEER QLSRSTPSLN 2520
KMSHEDSDES SEEDLTASQI LEHSDLIMNL SPSEEANPME LLTSACDSAP ADPHSFNTRM 2580
ANFEASLPDI NNLQISEGSK AEAVPEEEDT TVHEDDLSSS INELPAAFEC SDSFSLDMTE 2640
AEEKGNRGLD QYTLASFGEG DRGVSPPPSP FFSAILAAFQ PAACDDAEEA WRSHINQLMC 2700
DSDGSCAVYT FHVFSSLFKN IQKRFCFLTC DAASYLGDNL RGIGSKFVSS SQMLTSCSEC 2760
PTLFVDAETL LSCGLLDKLK FSVLELQEYL DTYNNRKEAT LSWLANCKAT FAGGSRDGVI 2820
TCQPGDSEEK QLELCQRLYK LHFQLLLLYQ SYCKLIGQVH EVSSVPELLN MSRELSDLKR 2880
NLKEATAAIA TDPLYIEGAW SEPTFTSTEA AIQSMLECLK NNELGKALRQ IKECRSLWPN 2940
DIFGSSSDDE VQTLLNIYFR HQTLGQTGTY ALVGSNHSLT EICTKLMELN MEIRDMIRRA 3000
QNYRVLTAFL PDSSVSGTSL 3020 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. 
Interpro
 IPR025614; Cell_morpho_N.
 IPR025481; Cell_Morphogen_C. 
Pfam
 PF14225; MOR2-PAG1_C
 PF14222; MOR2-PAG1_N 
SMART
  
PROSITE
  
PRINTS