Tag | Content |
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CPLM ID | CPLM-024772 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein furry homolog |
Protein Synonyms/Alias | |
Gene Name | Fry |
Gene Synonyms/Alias | Kiaa4143 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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1821 | TPKNQNSKSAEQLSN | ubiquitination | [1] | 1878 | FQIFRALKQPLSAHA | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. |
Sequence Annotation | MOD_RES 213 213 Phosphotyrosine (By similarity). MOD_RES 1936 1936 Phosphoserine (By similarity). MOD_RES 2516 2516 Phosphothreonine; by CDK1. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 3020 AA |
Protein Sequence | MASQQDSGFF EISIKYLLKS WSNASPVGNG YIKPPVPPAS GTHREKGPPA MLPINVDPDS 60 KPGEYVLKSL FVNFTTQAER KIRIIMAEPL EKPLTKSLQR GEDPQFDQVI SSMSSLSEYC 120 LPSILRTLFD WYKRQNGIED ESHEYRPRTS NKSKSDEQQR DYLMERRDLA IDFIFSLVLI 180 EVLKQIPLHP VIDSLIHDII NLAFKHFKYK EGYLGPNTGN MHIVADLYAE VIGVLAQAKF 240 PAVKKKFMAE LKELRHKEQS PYVVQSIISL IMGMKFFRIK MYPVEDFEAS LQFMQECAHY 300 FLEVKDKDIK HALAGLFVEI LVPVAAAVKN EVNVPCLRNF VESLYDTTLE LSSRKKHSLA 360 LYPLVTCLLC VSQKQLFLNR WHVFLNNCLS NLKNKDPKMA RVALESLYRL LWVYMIRIKC 420 ESNTATQSRL ITITTTLFPK GSRGVVPRDM PLNIFVKIIQ FIAQERLDFA MKEIIFDFLC 480 VGKPAKAFSL NPERMNIGLR AFLVIADSLQ QKDGEPPMPV TGAVLPSGNT LRVKKTYLSK 540 TLTEEEAKMI GMSLYYSQVR KAVGNILRHL DKEVGRCMML TNVQMLNKEP EDMITGERKP 600 KIDLFRTCVA AIPRLLPDGM SKLELIDLLA RLSIHMDDEL RHIAQNSLQG LLVDFSDWRE 660 DVLFGFTNFL LREVNDMHHT LLDSSLKLLL QLLTQWKLVI QTQGRAYEQA NKIRNSELIP 720 NGSSHRMQSE RGPHCSVLHA VEGFALVLLC SFQVATRKLS VLILKEIRAL FLALGQPEDD 780 DRPMIDVMDQ LSSSILESFI HVAVSDSATL PPTHNVDLQW LVEWNAVLVN SHYDVKSPSH 840 VWIFAQSVKD PWVLCLFSFL RQENLPKHCP TALSYAWPYA FTRLQSVMPL VDPNSPVNAK 900 KTSTASSGDN YVTLWRNYLI LCFGVAKPSI MSPGHLRAST PEIMATTPDG TVSYDNKAIG 960 TPSVGVLLKQ LVPLMRLESI EITESLVLGF GRTNSLVFRE LVEELHPLMK EALERRPENK 1020 KRRERRDLLR LQLLRIFELL ADAGVISDST NGALERDTLA LGALFLEYVD LTRMLLEAEN 1080 DKEVEILKDI RAHFSAMVAN LIQCVPVHHR RFLFPQQSLR HHLFILFSQW AGPFSIMFTP 1140 LDRYSDRNHQ ITRYQYCALK AMSAVLCCGP VFDNVGLSPD GYLYKWLDNI LACQDLRVHQ 1200 LGCEVVMLLL ELNPDQINLF NWAIDRCYTG SYQLASGCFK AIATVCGNRN YPFDIVTLLN 1260 LVLFKASDTN REIYEVSMQL MQILEAKLFV HSKKVAEQRP GSILYGTHGP LPPLYSVSLA 1320 LLSCELARMY PELTLPLFSE VSQRFPTTHP NGRQIMLTYL LPWLHNIELV DSRLLLPGSS 1380 PSSPEDEVKD REGEVTASHG LKGNGWGSPE ATSLVLNNLM YMTAKYGDEV PGAEMENAWN 1440 ALANNEKWSN NLRVTLQFLI SLCGVSSDTI LLPYIKKVAT YLCRNNTIQT MEELLFELQQ 1500 TEPVNPIVQH CDNPPFYRFT ASSKASAAAS GTTSSSNTVV AGQDSFPDPE ESKILKESDD 1560 RFSNVIRAHT RLESRYSNSS GGSYDEDKND PISPYTGWLL SITEAKQPQP LPMPCSGGCW 1620 APLVDYLPET ITPRGPLHRC NIAVIFMTEM VVDHSVREDW ALHLPLLLHA VFLGLDHYRP 1680 EVFEHSKKLL LHLLIALSCN SNFHAIASVL LQTREMGEAK TLTMQPAYQP EYLYTGGFDF 1740 LREDQSSPVP DSGLNSSSTS SSISLGGSSG NLPQMTQEVE DVEAATETDE KASKLIEFLT 1800 TRAFGPLWCH EDITPKNQNS KSAEQLSNFL RHVVSVFKDS RSGFHLEQHL SEVALQTALA 1860 SSSRHYAGRS FQIFRALKQP LSAHALSDLL SRLVEVIGEH GDEIQGYVME ALLTLEAAVD 1920 NLSDCLKNSD LFTVLSRSSS PDLSSSSKLT ASRKSTGQLN VNPGTPGSGG GGGGSGNTTT 1980 AERSRHQRSF SVPKKFGVVD RSSDPPRSAT LDRIQACTQQ GLSSKTRSNS SLKESLTDPS 2040 HVSHPTNLLA TIFWVTVALM ESDFEFEYLM ALRLLNRLLA HMPLEKAENR EKLEKLQAQL 2100 KWADFPGLQQ LLLKGFTSLT TTDLTLQLFS LLTSVSKVPM VDSSQAIGFP LNVLCLLPQL 2160 IQHFENPNQF CKDIAERIAQ VCLEEKNPKL SNLAHVMTLY KTHSYTRDCA TWVNVVCRYL 2220 HEAYADITLN MVTYLAELLE KGLPSMQQPL LQVIYSLLSY MDLSVVPVKQ FNMEVLKTIE 2280 KYVQSIHWRE ALNILKLVVS RSASLVLPSY QHSDLSKIEL HRVWTSASKE LPGKTLDFHF 2340 DISETPIIGR RYDELQNSSG RDGKPRAMAV TRSASSTSSG SNSNVLVPVS WKRPQYSQKR 2400 TKEKLVHVLS LCGQEVGLSK NPSVIFSSCG DLDLPEHQTS LVSSEDGPRE QENMDDTNSE 2460 QQFRVFRDFD FLDVELEDGE GESMDNFNWG VRRRSLDSLD KCDMQILEER QLSRSTPSLN 2520 KMSHEDSDES SEEDLTASQI LEHSDLIMNL SPSEEANPME LLTSACDSAP ADPHSFNTRM 2580 ANFEASLPDI NNLQISEGSK AEAVPEEEDT TVHEDDLSSS INELPAAFEC SDSFSLDMTE 2640 AEEKGNRGLD QYTLASFGEG DRGVSPPPSP FFSAILAAFQ PAACDDAEEA WRSHINQLMC 2700 DSDGSCAVYT FHVFSSLFKN IQKRFCFLTC DAASYLGDNL RGIGSKFVSS SQMLTSCSEC 2760 PTLFVDAETL LSCGLLDKLK FSVLELQEYL DTYNNRKEAT LSWLANCKAT FAGGSRDGVI 2820 TCQPGDSEEK QLELCQRLYK LHFQLLLLYQ SYCKLIGQVH EVSSVPELLN MSRELSDLKR 2880 NLKEATAAIA TDPLYIEGAW SEPTFTSTEA AIQSMLECLK NNELGKALRQ IKECRSLWPN 2940 DIFGSSSDDE VQTLLNIYFR HQTLGQTGTY ALVGSNHSLT EICTKLMELN MEIRDMIRRA 3000 QNYRVLTAFL PDSSVSGTSL 3020 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
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