CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022058
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic translation initiation factor 4E transporter 
Protein Synonyms/Alias
 4E-T; eIF4E transporter; Eukaryotic translation initiation factor 4E nuclear import factor 1 
Gene Name
 EIF4ENIF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
406LEMLQKAKVDLKPLLubiquitination[1]
420LSSLSANKEKLKESSubiquitination[1]
446EAGLKGLKVDQQVKNubiquitination[1]
452LKVDQQVKNSTPFMAubiquitination[1]
486GDMTAFNKLVSTMKAacetylation[2]
486GDMTAFNKLVSTMKAubiquitination[1]
492NKLVSTMKASGTLPSubiquitination[1, 3]
502GTLPSQPKVSRNLESubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism. 
Sequence Annotation
 REGION 30 36 EIF4E-binding.
 MOTIF 195 211 Nuclear localization signal.
 MOTIF 438 447 Nuclear export signal.
 MOTIF 613 638 Nuclear export signal.
 MOD_RES 5 5 Phosphoserine.
 MOD_RES 78 78 Phosphoserine (By similarity).
 MOD_RES 120 120 Phosphoserine.
 MOD_RES 136 136 Phosphoserine.
 MOD_RES 138 138 Phosphoserine.
 MOD_RES 301 301 Phosphoserine.
 MOD_RES 345 345 Phosphoserine.
 MOD_RES 486 486 N6-acetyllysine.
 MOD_RES 513 513 Phosphoserine.
 MOD_RES 564 564 Phosphoserine.
 MOD_RES 587 587 Phosphoserine.
 MOD_RES 693 693 Phosphoserine.
 MOD_RES 920 920 Phosphoserine.
 MOD_RES 951 951 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 985 AA 
Protein Sequence
MDRRSMGETE SGDAFLDLKK PPASKCPHRY TKEELLDIKE LPHSKQRPSC LSEKYDSDGV 60
WDPEKWHASL YPASGRSSPV ESLKKELDTD RPSLVRRIVD PRERVKEDDL DVVLSPQRRS 120
FGGGCHVTAA VSSRRSGSPL EKDSDGLRLL GGRRIGSGRI ISARTFEKDH RLSDKDLRDL 180
RDRDRERDFK DKRFRREFGD SKRVFGERRR NDSYTEEEPE WFSAGPTSQS ETIELTGFDD 240
KILEEDHKGR KRTRRRTASV KEGIVECNGG VAEEDEVEVI LAQEPAADQE VPRDAVLPEQ 300
SPGDFDFNEF FNLDKVPCLA SMIEDVLGEG SVSASRFSRW FSNPSRSGSR SSSLGSTPHE 360
ELERLAGLEQ AILSPGQNSG NYFAPIPLED HAENKVDILE MLQKAKVDLK PLLSSLSANK 420
EKLKESSHSG VVLSVEEVEA GLKGLKVDQQ VKNSTPFMAE HLEETLSAVT NNRQLKKDGD 480
MTAFNKLVST MKASGTLPSQ PKVSRNLESH LMSPAEIPGQ PVPKNILQEL LGQPVQRPAS 540
SNLLSGLMGS LEPTTSLLGQ RAPSPPLSQV FQTRAASADY LRPRIPSPIG FTPGPQQLLG 600
DPFQGMRKPM SPITAQMSQL ELQQAALEGL ALPHDLAVQA ANFYQPGFGK PQVDRTRDGF 660
RNRQQRVTKS PAPVHRGNSS SPAPAASITS MLSPSFTPTS VIRKMYESKE KSKEEPASGK 720
AALGDSKEDT QKASEENLLS SSSVPSADRD SSPTTNSKLS ALQRSSCSTP LSQANRYTKE 780
QDYRPKATGR KTPTLASPVP TTPFLRPVHQ VPLVPHVPMV RPAHQLHPGL VQRMLAQGVH 840
PQHLPSLLQT GVLPPGMDLS HLQGISGPIL GQPFYPLPAA SHPLLNPRPG TPLHLAMVQQ 900
QLQRSVLHPP GSGSHAAAVS VQTTPQNVPS RSGLPHMHSQ LEHRPSQRSS SPVGLAKWFG 960
SDVLQQPLPS MPAKVISVDE LEYRQ 985 
Gene Ontology
 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
 GO:0008565; F:protein transporter activity; TAS:ProtInc. 
Interpro
 IPR018862; eIF4E_transporter. 
Pfam
 PF10477; EIF4E-T 
SMART
  
PROSITE
  
PRINTS