UniProt Accession

 TSN6_HUMAN; O43657; Q54A42; Q6IAN9 

Genbank Protein ID

 AF053453; AF043906; U84895; AF133426; AY358825; AB097016; BT006977; CR457115; AL035608; CH471115; BC012389 

Genbank Nucleotide ID

 AAC69710.1; AAC64257.1; AAD00560.1; AAF08365.1; AAQ89184.1; BAC77369.1; AAP35623.1; CAG33396.1; CAB55681.1; EAX02811.1; AAH12389.1 

Protein Name

 Tetraspanin-6 

Protein Synonyms/Alias

 Tspan-6; A15 homolog; Putative NF-kappa-B-activating protein 321; T245 protein; Tetraspanin TM4-D; Transmembrane 4 superfamily member 6 

Gene Name

 TSPAN6 

Gene Synonyms/Alias

 TM4SF6; UNQ767/PRO1560 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
123	HEIKNSFKNNYEKAL	methylation	[1]
123	HEIKNSFKNNYEKAL	ubiquitination	[2]
128	SFKNNYEKALKQYNS	ubiquitination	[2]
131	NNYEKALKQYNSTGD	ubiquitination	[2, 3]
171	DTNYYSEKGFPKSCC	ubiquitination	[2]
179	GFPKSCCKLEDCTPQ	ubiquitination	[4]
191	TPQRDADKVNNEGCF	ubiquitination	[3]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

 CARBOHYD 134 134 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB. 

Interpro

 IPR000301; Tetraspanin.
 IPR018499; Tetraspanin/Peripherin.
 IPR018503; Tetraspanin_CS.
 IPR008952; Tetraspanin_EC2. 

Pfam

 PF00335; Tetraspannin 

SMART

  

PROSITE

 PS00421; TM4_1 

PRINTS

 PR00259; TMFOUR.