UniProt Accession

 PDIA3_RAT; P11598 

Genbank Protein ID

 X12355; D63378; BC062393 

Genbank Nucleotide ID

 CAA30916.1; BAA09695.1; AAH62393.1 

Protein Name

 Protein disulfide-isomerase A3 

Protein Synonyms/Alias

 58 kDa glucose-regulated protein; 58 kDa microsomal protein; p58; Disulfide isomerase ER-60; Endoplasmic reticulum resident protein 57; ER protein 57; ERp57; Endoplasmic reticulum resident protein 60; ER protein 60; ERp60; HIP-70; Q-2 

Gene Name

 Pdia3 

Gene Synonyms/Alias

 Erp60; Grp58 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
75	EAAATRLKGIVPLAK	acetylation	[1]
129	DGIVSHLKKQAGPAS	acetylation	[1]
146	LRTEDEFKKFISDKD	acetylation	[1]
152	FKKFISDKDASVVGF	acetylation	[1]
173	DGHSEFLKAASNLRD	acetylation	[1]
214	RPLHLANKFEDKIVA	acetylation	[1]
218	LANKFEDKIVAYTEK	acetylation	[1]
225	KIVAYTEKKMTSGKI	acetylation	[1]
296	TFLDAGHKLNFAVAS	acetylation	[1]
332	VVAIRTAKGEKFVMQ	acetylation	[1]
335	IRTAKGEKFVMQEEF	acetylation	[1]
362	EYFDGNLKRYLKSEP	acetylation	[1]
366	GNLKRYLKSEPIPET	acetylation	[1]
415	HCKNLEPKYKELGEK	acetylation	[1]
417	KNLEPKYKELGEKLS	acetylation	[1]
422	KYKELGEKLSKDPNI	acetylation	[1]
425	ELGEKLSKDPNIVIA	acetylation	[1]
433	DPNIVIAKMDATAND	acetylation	[1]
448	VPSPYEVKGFPTIYF	acetylation	[1]
460	IYFSPANKKLTPKKY	acetylation	[1]
494	PPIIQEEKPKKKKKA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

 DOMAIN 25 133 Thioredoxin 1.
 DOMAIN 343 485 Thioredoxin 2.
 MOTIF 502 505 Prevents secretion from ER.
 ACT_SITE 57 57 Nucleophile (By similarity).
 ACT_SITE 60 60 Nucleophile (By similarity).
 ACT_SITE 406 406 Nucleophile (By similarity).
 ACT_SITE 409 409 Nucleophile (By similarity).
 DISULFID 57 60 Redox-active; alternate (By similarity).
 DISULFID 57 57 Interchain (with C-115 in TAPBP);
 DISULFID 85 92 By similarity.
 DISULFID 406 409 Redox-active (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Isomerase; Redox-active center; Reference proteome; Repeat; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 505 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0003756; F:protein disulfide isomerase activity; IEA:EC.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0006457; P:protein folding; IEA:GOC. 

Interpro

 IPR005788; Disulphide_isomerase.
 IPR005792; Prot_disulphide_isomerase.
 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS

 PR00421; THIOREDOXIN.