UniProt Accession

 ALF_BACSU; P13243 

Genbank Protein ID

 M22039; S42590; Z49782; AL009126 

Genbank Nucleotide ID

 AAA16803.1; AAB22716.1; CAA89873.1; CAB15729.1 

Protein Name

 Probable fructose-bisphosphate aldolase 

Protein Synonyms/Alias

 FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase 

Gene Name

 fbaA 

Gene Synonyms/Alias

 fba; fba1; tsr; BSU37120 

Created Date

 July 27, 2013 

Organism

 Bacillus subtilis (strain 168) 

NCBI Taxa ID

 224308 

Lysine Modification

Position	Peptide	Type	References
14	TEMLNTAKEKGYAVG	acetylation	[1]
68	KTVVAMVKALMEEYK	acetylation	[1]
193	GEPNLGFKEMEEIGK	acetylation	[1]
251	VRETLAAKPDEYDPR	acetylation	[1]
259	PDEYDPRKYLGPARE	acetylation	[1]

Reference

 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 

Functional Description

 Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (By similarity). 

Sequence Annotation

 REGION 210 212 Dihydroxyacetone phosphate binding (By
 REGION 231 234 Dihydroxyacetone phosphate binding (By
 ACT_SITE 85 85 Proton donor (By similarity).
 METAL 86 86 Zinc 1; catalytic (By similarity).
 METAL 107 107 Zinc 2 (By similarity).
 METAL 137 137 Zinc 2 (By similarity).
 METAL 181 181 Zinc 1; catalytic (By similarity).
 METAL 209 209 Zinc 1; catalytic (By similarity).
 BINDING 50 50 Glyceraldehyde 3-phosphate (By
 BINDING 182 182 Dihydroxyacetone phosphate; via amide
 MOD_RES 212 212 Phosphothreonine.
 MOD_RES 234 234 Phosphothreonine.  

Keyword

 Complete proteome; Direct protein sequencing; Glycolysis; Lyase; Metal-binding; Phosphoprotein; Reference proteome; Sporulation; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030388; P:fructose 1,6-bisphosphate metabolic process; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway.
 GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR011289; Fruc_bis_ald_class-2.
 IPR000771; Ketose_bisP_aldolase_II. 

Pfam

 PF01116; F_bP_aldolase 

SMART

  

PROSITE

 PS00602; ALDOLASE_CLASS_II_1
 PS00806; ALDOLASE_CLASS_II_2 

PRINTS