UniProt Accession

 MO4L2_MOUSE; Q9R0Q4; A2AEB2; Q3UL62; Q6DIB1; Q6ZQK7; Q8C201; Q8C6C2 

Genbank Protein ID

 AB025049; AK075946; AK088849; AK089963; AK129038; AK131944; AK145686; AK150401; AK150670; AK151570; AK160012; AK161610; AK164433; AK166637; AL671887; BC075653; BC088731 

Genbank Nucleotide ID

 BAA84687.1; BAC36075.1; BAC40611.1; BAC41017.1; BAC97848.1; BAE20890.1; BAE26588.1; BAE29527.1; BAE29752.1; BAE30512.1; BAE35559.1; BAE36491.1; BAE37786.1; BAE38909.1; CAM17215.1; AAH75653.1; AAH88731.1 

Protein Name

 Mortality factor 4-like protein 2 

Protein Synonyms/Alias

 MORF-related gene X protein; Sid 393; Transcription factor-like protein MRGX 

Gene Name

 Morf4l2 

Gene Synonyms/Alias

 Kiaa0026; Sid393 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
277	LFTASDYKVASADYH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity). 

Sequence Annotation

 DOMAIN 117 288 MRG.
 MOD_RES 71 71 Phosphoserine (By similarity).
 MOD_RES 262 262 Phosphotyrosine.
 MOD_RES 267 267 Phosphoserine.  

Keyword

 Chromatin regulator; Complete proteome; DNA damage; DNA repair; Growth regulation; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0051155; P:positive regulation of striated muscle cell differentiation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR008676; MRG.
 IPR026541; MRG_dom. 

Pfam

 PF05712; MRG 

SMART

  

PROSITE

 PS51640; MRG 

PRINTS