CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036688
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 La-related protein 1 
Protein Synonyms/Alias
  
Gene Name
 LARP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
162DYQFGYRKFDGVEGPubiquitination[1, 2]
257SLIFAALKDSKVVEIubiquitination[3]
268VVEIVDEKVRRREEPubiquitination[1, 2, 3]
334TEEVSNLKTLPKGLSubiquitination[4]
548PTDALANKLFGAPEPubiquitination[1, 2, 3, 4, 5]
587TPRTPQLKDSSQTSRubiquitination[1, 2]
600SRFYPVVKEGRTLDAubiquitination[1, 2, 4]
608EGRTLDAKMPR****ubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 611 AA 
Protein Sequence
MKEQEKGEGS DSKESPKTKS DESGEEKNGD EDCQRGGQKK KGNKHKWVPL QIDMKPEVPR 60
EKLASRPTRP PEPRHIPANR GEIKGSESAT YVPVAPPTPA WQPEIKPEPA WHDQDETSSV 120
KSDGAGGARA SFRGRGRGRG RGRGRGRGGT RTHFDYQFGY RKFDGVEGPR TPKYMNNITY 180
YFDNVSSTEL YSVDQELLKD YIKRQIEYYF SVDNLERDFF LRRKMDADGF LPITLIASFH 240
RVQALTTDIS LIFAALKDSK VVEIVDEKVR RREEPEKWPL PPIVDYSQTD FSQLLNCPEF 300
VPRQHYQKET ESAPGSPRAV TPVPTKTEEV SNLKTLPKGL SASLPDLDSE NWIEVKKRPR 360
PSPARPKKSE ESRFSHLTSL PQQLPSQQLM SKDQDEQEEL DFLFDEEMEQ MDGRKNTFTA 420
WSDEESDYEI DDRDVNKILI VTQTPHYMRR HPGGDRTGNH TSRAKMSAEL AKVINDGLFY 480
YEQDLWAEKF EPEYSQIKQE VENFKKVNMI SREQFDTLTP EPPVDPNQEV PPGPPRFQQV 540
PTDALANKLF GAPEPSTIAR SLPTTVPESP NYRNTRTPRT PRTPQLKDSS QTSRFYPVVK 600
EGRTLDAKMP R 611 
Gene Ontology
  
Interpro
 IPR006630; Lupus_La_RNA-bd.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF05383; La 
SMART
 SM00715; LA 
PROSITE
 PS50961; HTH_LA 
PRINTS