UniProt Accession

 IF4B_MOUSE; Q8BGD9; Q3TD64 

Genbank Protein ID

 AK045250; AK077423; AK170354 

Genbank Nucleotide ID

 BAC32280.1; BAC36793.1; BAE41740.1 

Protein Name

 Eukaryotic translation initiation factor 4B 

Protein Synonyms/Alias

 eIF-4B 

Gene Name

 Eif4b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
223	GDDSFGDKYRDRYDS	acetylation	[1]
365	ASIFGGAKPVDTAAR	acetylation	[1, 2]
480	VMPAPPPKENAWVKR	acetylation	[1]
557	GGSRDHWKDLDRKDG	acetylation	[1, 2]
586	PEENPASKFSSASKY	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F (By similarity). 

Sequence Annotation

 DOMAIN 96 173 RRM.
 MOD_RES 93 93 Phosphoserine.
 MOD_RES 192 192 Phosphoserine (By similarity).
 MOD_RES 219 219 Phosphoserine (By similarity).
 MOD_RES 283 283 Phosphoserine (By similarity).
 MOD_RES 406 406 Phosphoserine.
 MOD_RES 412 412 Phosphothreonine (By similarity).
 MOD_RES 418 418 Phosphoserine (By similarity).
 MOD_RES 422 422 Phosphoserine; by RPS6KA1 and RPS6KB1 (By
 MOD_RES 425 425 Phosphoserine (By similarity).
 MOD_RES 445 445 Phosphoserine.
 MOD_RES 459 459 Phosphoserine (By similarity).
 MOD_RES 497 497 Phosphoserine.
 MOD_RES 498 498 Phosphoserine.
 MOD_RES 504 504 Phosphoserine (By similarity).
 MOD_RES 586 586 N6-acetyllysine (By similarity).
 MOD_RES 597 597 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 611 AA 

Protein Sequence

Gene Ontology

 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS