UniProt Accession

 ID2_HUMAN; Q02363 

Genbank Protein ID

 D13891; M97796; BC030639 

Genbank Nucleotide ID

 BAA02990.1; AAA58681.1; AAH30639.1 

Protein Name

 DNA-binding protein inhibitor ID-2 

Protein Synonyms/Alias

 Class B basic helix-loop-helix protein 26; bHLHb26; Inhibitor of DNA binding 2 

Gene Name

 ID2 

Gene Synonyms/Alias

 BHLHB26 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	SPVRSVRKNSLSDHS	ubiquitination	[1]

Reference

 [1] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266] 

Functional Description

 ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. 

Sequence Annotation

 DOMAIN 23 75 bHLH.
 MOTIF 106 115 Nuclear export signal (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Developmental protein; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 134 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IEA:Compara.
 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0043234; C:protein complex; ISS:UniProtKB.
 GO:0060612; P:adipose tissue development; IEA:Compara.
 GO:0003166; P:bundle of His development; IEA:Compara.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0071285; P:cellular response to lithium ion; IEA:Compara.
 GO:0090398; P:cellular senescence; ISS:UniProtKB.
 GO:0048557; P:embryonic digestive tract morphogenesis; ISS:UniProtKB.
 GO:0061031; P:endodermal digestive tract morphogenesis; ISS:UniProtKB.
 GO:0009649; P:entrainment of circadian clock; IEA:Compara.
 GO:0043353; P:enucleate erythrocyte differentiation; IEA:Compara.
 GO:0061030; P:epithelial cell differentiation involved in mammary gland alveolus development; ISS:UniProtKB.
 GO:0033598; P:mammary gland epithelial cell proliferation; ISS:UniProtKB.
 GO:0001656; P:metanephros development; IEA:Compara.
 GO:0001779; P:natural killer cell differentiation; IEA:Compara.
 GO:0045578; P:negative regulation of B cell differentiation; IEA:Compara.
 GO:0043392; P:negative regulation of DNA binding; IEA:Compara.
 GO:2000178; P:negative regulation of neural precursor cell proliferation; ISS:UniProtKB.
 GO:0045665; P:negative regulation of neuron differentiation; ISS:UniProtKB.
 GO:0048715; P:negative regulation of oligodendrocyte differentiation; IEA:Compara.
 GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Compara.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:GDB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:GDB.
 GO:0048663; P:neuron fate commitment; ISS:UniProtKB.
 GO:0021772; P:olfactory bulb development; IEA:Compara.
 GO:0014003; P:oligodendrocyte development; IEA:Compara.
 GO:0048541; P:Peyer's patch development; IEA:Compara.
 GO:0048711; P:positive regulation of astrocyte differentiation; IEA:Compara.
 GO:0045777; P:positive regulation of blood pressure; ISS:UniProtKB.
 GO:0045787; P:positive regulation of cell cycle; IEA:Compara.
 GO:0071158; P:positive regulation of cell cycle arrest; ISS:UniProtKB.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Compara.
 GO:0045600; P:positive regulation of fat cell differentiation; IEA:Compara.
 GO:0045651; P:positive regulation of macrophage differentiation; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
 GO:0071931; P:positive regulation of transcription involved in G1/S phase of mitotic cell cycle; IC:BHF-UCL.
 GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IMP:BHF-UCL.
 GO:0019216; P:regulation of lipid metabolic process; IEA:Compara. 

Interpro

 IPR011598; bHLH_dom.
 IPR026052; DNA-bd_prot-inh. 

Pfam

 PF00010; HLH 

SMART

 SM00353; HLH 

PROSITE

 PS50888; BHLH 

PRINTS