CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000198
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Copper transport protein ATOX1 
Protein Synonyms/Alias
 Metal transport protein ATX1 
Gene Name
 Atox1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
3*****MPKHEFSVDMacetylation[1]
25AVSRVLNKLGGVEFNubiquitination[2]
39NIDLPNKKVCIDSEHubiquitination[2]
57TLLATLNKTGKAVSYubiquitination[2]
60ATLNKTGKAVSYLGPacetylation[1, 3, 4, 5, 6, 7, 8]
60ATLNKTGKAVSYLGPsuccinylation[7]
60ATLNKTGKAVSYLGPubiquitination[2]
68AVSYLGPK*******acetylation[8]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [5] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [6] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [7] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [8] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
 Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity). 
Sequence Annotation
 DOMAIN 2 68 HMA.
 METAL 12 12 Copper (By similarity).
 METAL 15 15 Copper (By similarity).  
Keyword
 Chaperone; Complete proteome; Copper; Copper transport; Ion transport; Metal-binding; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 68 AA 
Protein Sequence
MPKHEFSVDM TCEGCAEAVS RVLNKLGGVE FNIDLPNKKV CIDSEHSSDT LLATLNKTGK 60
AVSYLGPK 68 
Gene Ontology
 GO:0016531; F:copper chaperone activity; IEA:Compara.
 GO:0006878; P:cellular copper ion homeostasis; IMP:MGI.
 GO:0006825; P:copper ion transport; IMP:MGI.
 GO:0006979; P:response to oxidative stress; IEA:Compara. 
Interpro
 IPR017969; Heavy-metal-associated_CS.
 IPR006121; HeavyMe-assoc_HMA. 
Pfam
 PF00403; HMA 
SMART
  
PROSITE
 PS01047; HMA_1
 PS50846; HMA_2 
PRINTS