CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016468
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CDKN2A-interacting protein 
Protein Synonyms/Alias
 Collaborator of ARF 
Gene Name
 Cdkn2aip 
Gene Synonyms/Alias
 Carf 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
92YPQKVMDKILSMAEGubiquitination[1]
405QASESSVKFACRKLTubiquitination[1]
428PFFNRLYKTVAWKLVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways (By similarity). 
Sequence Annotation
 DOMAIN 445 520 DRBM.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 124 124 Phosphoserine (By similarity).
 MOD_RES 340 340 Phosphothreonine (By similarity).  
Keyword
 Acetylation; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 563 AA 
Protein Sequence
MAQEVSEYLS QNPRVAAWVE TLRCEGETDK HWRHRREFLL RNAGDLVPAT DETADAESGA 60
RTRQLQQLVS FSMAWANHVF LGCRYPQKVM DKILSMAEGI KVTDAPIHTT RDELVAKVKK 120
RGISSSNEGV EEPSKKRAVE GKNNSSVERD HGKKSAKTDR SAAQQENSSP SRGSSTKSES 180
GGTSARSSSS GSHQDSATSE GDRSVCSQSS SNSSQVTAGS GKALESEAPH KRGSASFVSS 240
LLKSSMNSHM TQSTDNRQQS GSPKKGALEG SSGSASQSSS EIEVPLLGSS GSAEVELPLL 300
SCKSSSETAS SGLTSKSSSE ANISSSVSKN SSSSGSSLLT PQSSSTNPSL LTSKSTAQVA 360
ASLLATKSGA SLGSVSQLAA KSGSQSSTSQ LPSKSTSQAS ESSVKFACRK LTNEDIKQKQ 420
PFFNRLYKTV AWKLVAVGGF SPTVNHGELL NAAIEALKAT LDVFFVPLKE LADLPQNKSS 480
QESIVCELRC KSVYLGTGCG KSKENAKAVA SREALKLFLK KKVVVKICKR KYRGSEIEDL 540
VLLDEEARPV NLPPALKHPQ ELL 563 
Gene Ontology
 GO:0001652; C:granular component; IEA:Compara.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
 GO:0030308; P:negative regulation of cell growth; IEA:Compara.
 GO:0009967; P:positive regulation of signal transduction; IEA:Compara.
 GO:0031647; P:regulation of protein stability; IEA:Compara. 
Interpro
 IPR001159; Ds-RNA-bd.
 IPR014720; dsRNA-bd-like_dom.
 IPR021859; DUF3469. 
Pfam
 PF11952; DUF3469 
SMART
  
PROSITE
 PS50137; DS_RBD 
PRINTS