UniProt Accession

 CPDA_ECOLI; P0AEW4; P36650; Q2M9G8 

Genbank Protein ID

 D16557; U28377; U00096; AP009048 

Genbank Nucleotide ID

 BAA03989.1; AAA69200.1; AAC76068.1; BAE77088.1 

Protein Name

 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA 

Protein Synonyms/Alias

 3',5'-cyclic AMP phosphodiesterase; cAMP phosphodiesterase 

Gene Name

 cpdA 

Gene Synonyms/Alias

 icc; b3032; JW3000 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
150	QLEWLERKLADAPER	acetylation	[1]
192	ELDTVLAKFPHVKYL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Specific for cAMP. 

Sequence Annotation

 NP_BIND 94 95 cAMP (By similarity).
 METAL 22 22 Metal cation 1 (By similarity).
 METAL 24 24 Metal cation 1 (By similarity).
 METAL 64 64 Metal cation 1 (By similarity).
 METAL 64 64 Metal cation 2 (By similarity).
 METAL 94 94 Metal cation 2 (By similarity).
 METAL 164 164 Metal cation 2 (By similarity).
 METAL 203 203 Metal cation 2 (By similarity).
 METAL 205 205 Metal cation 1 (By similarity).
 BINDING 24 24 cAMP (By similarity).
 BINDING 64 64 cAMP (By similarity).
 BINDING 205 205 cAMP (By similarity).  

Keyword

 cAMP; Complete proteome; Direct protein sequencing; Hydrolase; Metal-binding; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 275 AA 

Protein Sequence

Gene Ontology

 GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:EcoCyc.
 GO:0008198; F:ferrous iron binding; IDA:EcoCyc.
 GO:0000166; F:nucleotide binding; IEA:HAMAP. 

Interpro

 IPR013622; Calcineurin-like_phos_C.
 IPR026575; cAMP_Pdiest_CpdA.
 IPR004843; Metallo_PEstase_dom. 

Pfam

 PF00149; Metallophos 

SMART

  

PROSITE

  

PRINTS