UniProt Accession

 CYOB_ECOLI; P0ABI8; P18401; Q2MBZ5 

Genbank Protein ID

 J05492; U82664; U00096; AP009048 

Genbank Nucleotide ID

 AAA23632.1; AAB40187.1; AAC73534.1; BAE76211.1 

Protein Name

 Ubiquinol oxidase subunit 1 

Protein Synonyms/Alias

 Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I 

Gene Name

 cyoB 

Gene Synonyms/Alias

 b0431; JW0421 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
575	KEKGEAYKKPDHYEE	acetylation	[1]
645	VPVAEIEKLENQHFD	acetylation	[1]
656	QHFDEITKAGLKNGN	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer. 

Sequence Annotation

 METAL 106 106 Iron (heme B axial ligand) (Probable).
 METAL 284 284 Copper B (Probable).
 METAL 288 288 Copper B (Probable).
 METAL 333 333 Copper B (Probable).
 METAL 334 334 Copper B (Probable).
 METAL 419 419 Iron (heme O axial ligand) (Probable).
 METAL 421 421 Iron (heme B axial ligand) (Probable).
 CROSSLNK 284 288 1'-histidyl-3'-tyrosine (His-Tyr) (By  

Keyword

 3D-structure; Cell inner membrane; Cell membrane; Complete proteome; Copper; Electron transport; Heme; Hydrogen ion transport; Ion transport; Iron; Membrane; Metal-binding; Oxidoreductase; Reference proteome; Respiratory chain; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 663 AA 

Protein Sequence

Gene Ontology

 GO:0009319; C:cytochrome o ubiquinol oxidase complex; IDA:EcoCyc.
 GO:0005887; C:integral to plasma membrane; IDA:EcoliWiki.
 GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
 GO:0005507; F:copper ion binding; IDA:EcoCyc.
 GO:0009486; F:cytochrome bo3 ubiquinol oxidase activity; IDA:EcoCyc.
 GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
 GO:0009055; F:electron carrier activity; IDA:EcoCyc.
 GO:0020037; F:heme binding; IDA:EcoCyc.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IDA:EcoCyc.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016682; F:oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor; IEA:InterPro.
 GO:0015453; F:oxidoreduction-driven active transmembrane transporter activity; IDA:EcoCyc.
 GO:0048039; F:ubiquinone binding; IDA:EcoCyc.
 GO:0019646; P:aerobic electron transport chain; IMP:EcoCyc.
 GO:0015990; P:electron transport coupled proton transport; IMP:EcoCyc. 

Interpro

 IPR000883; Cyt_c_Oxase_su1.
 IPR023615; Cyt_c_Oxase_su1_BS.
 IPR023616; Cyt_c_Oxase_su1_dom.
 IPR014207; Cyt_c_ubiqinol_oxidase_su1. 

Pfam

 PF00115; COX1 

SMART

  

PROSITE

 PS50855; COX1
 PS00077; COX1_CUB 

PRINTS

 PR01165; CYCOXIDASEI.