UniProt Accession

 IF2A_YEAST; P20459; D6VWI2; E9P8T6 

Genbank Protein ID

 M25552; X87611; Z49507; AY557876; BK006943 

Genbank Nucleotide ID

 AAA70332.1; CAA60929.1; CAA89529.1; AAS56202.1; DAA08798.1 

Protein Name

 Eukaryotic translation initiation factor 2 subunit alpha 

Protein Synonyms/Alias

 eIF-2-alpha 

Gene Name

 SUI2 

Gene Synonyms/Alias

 TIF211; YJR007W; J1429 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
137	IAWPLSRKFGHAYEA	acetylation	[1]
183	RLTPQAVKIRADVEV	ubiquitination	[2]
221	EQMQVKVKLVAAPLY	ubiquitination	[2]
237	LTTQALDKQKGIEQL	acetylation	[1]
237	LTTQALDKQKGIEQL	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. 

Sequence Annotation

 DOMAIN 17 88 S1 motif.
 MOD_RES 52 52 Phosphoserine; by GCN2.
 MOD_RES 292 292 Phosphoserine.
 MOD_RES 294 294 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 304 AA 

Protein Sequence

Gene Ontology

 GO:0005850; C:eukaryotic translation initiation factor 2 complex; IMP:SGD.
 GO:0043614; C:multi-eIF complex; IDA:SGD.
 GO:0005840; C:ribosome; TAS:SGD.
 GO:0003743; F:translation initiation factor activity; TAS:SGD. 

Interpro

 IPR012340; NA-bd_OB-fold.
 IPR003029; Rbsml_prot_S1_RNA-bd_dom.
 IPR022967; RNA-binding_domain_S1.
 IPR024055; TIF2_asu_C.
 IPR024054; TIF2_asu_middle.
 IPR011488; TIF_2_asu. 

Pfam

 PF07541; EIF_2_alpha
 PF00575; S1 

SMART

 SM00316; S1 

PROSITE

 PS50126; S1 

PRINTS