CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015505
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Beclin 1-associated autophagy-related key regulator 
Protein Synonyms/Alias
 Barkor; Autophagy-related protein 14-like protein; Atg14L 
Gene Name
 ATG14 
Gene Synonyms/Alias
 KIAA0831 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
236MTSSTVSKLAEARRTubiquitination[1]
328LDVNLPKKLCNSEFCubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. 
Sequence Annotation
 REGION 413 492 BATS (By similarity).
 MOD_RES 29 29 Phosphoserine.
 MOD_RES 416 416 Phosphoserine.
 MOD_RES 429 429 Phosphothreonine.  
Keyword
 Alternative splicing; Autophagy; Coiled coil; Complete proteome; Cytoplasm; Endoplasmic reticulum; Membrane; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 492 AA 
Protein Sequence
MASPSGKGAR ALEAPGCGPR PLARDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ 60
SGDFVYFDGR DRERFIDKKE RLSRLKSKQE EFQKEVLKAM EGKWITDQLR WKIMSCKMRI 120
EQLKQTICKG NEEMEKNSEG LLKTKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT 180
IDLRSHYERL ANLRRSHILE LTSVIFPIEE VKTGVRDPAD VSSESDSAMT SSTVSKLAEA 240
RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY SWVEEKKTTQ GPDMEQSNPA 300
YTISAALCYA TQLVNILSHI LDVNLPKKLC NSEFCGENLS KQKFTRAVKK LNANILYLCF 360
SQHVNLDQLQ PLHTLRNLMY LVSPSSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDESG 420
DERVSDEETD LGTDWENLPS PRFCDIPSQS VEVSQSQSTQ ASPPIASSSA GGMISSAAAS 480
VTSWFKAYTG HR 492 
Gene Ontology
 GO:0005776; C:autophagic vacuole; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0034045; C:pre-autophagosomal structure membrane; IDA:UniProtKB.
 GO:0000045; P:autophagic vacuole assembly; IMP:UniProtKB.
 GO:0010508; P:positive regulation of autophagy; IEA:InterPro. 
Interpro
 IPR018791; UV_resistance/autophagy_Atg14. 
Pfam
 PF10186; Atg14 
SMART
  
PROSITE
  
PRINTS