CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016710
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WASH complex subunit strumpellin 
Protein Synonyms/Alias
  
Gene Name
 Kiaa0196 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
202YSSQPGAKRPPNYPEubiquitination[1]
324TLDLANVKEQASRYAubiquitination[1]
461ADVFSGVKPLTRVEKubiquitination[1]
910RTVQETLKMLMSAVNacetylation[2]
920MSAVNPLKSIVANSSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599] 
Functional Description
 Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1159 AA 
Protein Sequence
MLDFLAENNL CGQAILRIVS CGNAIIAEVL RLSEFIPAVF LLKDRADQQR YGDIIFDFSY 60
FKGPEFWESK LEAKPELQDL DEEFRENNIE IVTRFYLAFQ SVHKYIVDLN RYLDDLNEGV 120
YIQQTLETVL LSEDGKQLLC EALYLYGVML LVIDQKIEGE VRERMLVSYY RYSAARSSAD 180
SNMDDICKLL RSTGYSSQPG AKRPPNYPES YFQRVPINET FISMVIGRLR SDDIYNQVSA 240
YPLPEHRSTA LANQAAMLYV ILYFEPSILH THQAKMREIV DKYFPDNWVI SIYMGITVNL 300
ADAWEPYKAA KTALNNTLDL ANVKEQASRY ASVSDRVRAQ VQQFLKEGYL REEVLLDNIP 360
RLLNCLRDCN VAIRWLMLHT ADSACDPNNK RLRQIKDQIL ADSRYNPKIL FQLLLDTAQF 420
EFILKEMFKQ MLSEKQSKWE HYKKEGSERM TELADVFSGV KPLTRVEKNE NLQAWFREIS 480
KQILSLNYDD STAAGRKTVQ LIQALEEVQE FHQLESNLQV CQFLADTRKF LHQMIRTINI 540
KEEVLITVQI IGDLSFAWQL IDSFTSIMQE SIRVNPSMVT KLRATFLKLA SALDLPLLRI 600
NQANSPDLLS VSQYYSGELV SYVRKVLQII PESMFTSLLK IIKLQTHDIM EVPTRLDKDK 660
LRDYAQLGPR YEVAKLTHAI SIFTEGILMM KTTLVGIIKV DPKQLLEDGI RKELVKRVAF 720
ALHRGLIFNP RAKPSELMPK LKELGATMDG FHRSFEYIQD YVSIYGLKIW QEEVSRIINY 780
NVEQECNNFL RTKIQDWQSM YQSTHIPIPK FAPVDESITF IGRLCREILR ITDPKMTCYI 840
DQLNTWYDVK THQEVTSSRL FSEIQTTLGT FGLNGLDRLL CFMIVKELQN FLSMFQKIIL 900
KERTVQETLK MLMSAVNPLK SIVANSSKVY LSAITKTQKI WSAYLEAIMK VGQMQILRQQ 960
IANELNSSCR FDSRHLAAAL DNLNKALLAD IEAHYRDPSL PYPKEDNTLL YEITAYLEAA 1020
GIHNPLNKIY ITTKRLPYFP IVNFLFLIAQ LPKLQYNKNL GMVCRKPADP VDWPPLVLGL 1080
LTLLKQFHSR YTEQFLALIG QFIRSTMEQC TSQKMPEMPA DAVGALLFLE DYVRYTKLPR 1140
RVAEAHVPNF IFDEFRTVL 1159 
Gene Ontology
 GO:0005768; C:endosome; IDA:MGI.
 GO:0071203; C:WASH complex; ISS:UniProtKB.
 GO:0016197; P:endosomal transport; IMP:MGI. 
Interpro
 IPR019393; WASH_strumpellin. 
Pfam
 PF10266; Strumpellin 
SMART
  
PROSITE
  
PRINTS