CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033346
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 
Protein Synonyms/Alias
  
Gene Name
 INPP5D 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14HGNITRSKAEELLSRubiquitination[1]
24ELLSRTGKDGSFLVRubiquitination[1]
141TASSCEAKEVPFSNEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 222 AA 
Protein Sequence
MVPCWNHGNI TRSKAEELLS RTGKDGSFLV RASESISRAY ALCVLYRNCV YTYRILPNED 60
DKFTVQASEG VSMRFFTKLD QLIEFYKKEN MGLVTHLQYP VPLEEEDTGD DPEEDTVESV 120
VSPPELPPRN IPLTASSCEA KEVPFSNENP RATETSRPSL SETLFQRLQS MDTSGLPEEH 180
LKAIQDYLST QLAQDSEFVK TGSSSLPHLK KLTTLLCKEL YG 222 
Gene Ontology
 GO:0005622; C:intracellular; IEA:Compara.
 GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:Compara.
 GO:0034594; F:phosphatidylinositol trisphosphate phosphatase activity; IEA:Compara.
 GO:0008340; P:determination of adult lifespan; IEA:Compara.
 GO:0016064; P:immunoglobulin mediated immune response; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:Compara.
 GO:0030889; P:negative regulation of B cell proliferation; IEA:Compara.
 GO:0045779; P:negative regulation of bone resorption; IEA:Compara.
 GO:0050777; P:negative regulation of immune response; IEA:Compara.
 GO:0045409; P:negative regulation of interleukin-6 biosynthetic process; IEA:Compara.
 GO:0045656; P:negative regulation of monocyte differentiation; IEA:Compara.
 GO:0045659; P:negative regulation of neutrophil differentiation; IEA:Compara.
 GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Compara.
 GO:0009968; P:negative regulation of signal transduction; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0045579; P:positive regulation of B cell differentiation; IEA:Compara.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Compara. 
Interpro
 IPR000980; SH2. 
Pfam
 PF00017; SH2 
SMART
 SM00252; SH2 
PROSITE
 PS50001; SH2 
PRINTS
 PR00401; SH2DOMAIN.