UniProt Accession

 SURF6_HUMAN; O75683; Q5T8U1; Q9BRK9; Q9BTZ5; Q9UK24 

Genbank Protein ID

 AF186772; AL158826; CH471090; BC003001; BC006197; BC014878; AJ224639 

Genbank Nucleotide ID

 AAD56587.1; CAI12825.1; EAW88055.1; AAH03001.1; AAH06197.1; AAH14878.1; CAA12054.1 

Protein Name

 Surfeit locus protein 6 

Protein Synonyms/Alias

  

Gene Name

 SURF6 

Gene Synonyms/Alias

 SURF-6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MASLLAKDAYLQSL	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity). 

Sequence Annotation

 MOTIF 45 49 Nuclear localization signal (Potential).
 MOTIF 154 158 Nuclear localization signal (Potential).
 MOD_RES 74 74 Phosphoserine.
 MOD_RES 138 138 Phosphoserine.
 MOD_RES 229 229 Phosphothreonine.  

Keyword

 Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0001652; C:granular component; ISS:UniProtKB.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0042254; P:ribosome biogenesis; IEA:Compara. 

Interpro

 IPR007019; Surf6. 

Pfam

 PF04935; SURF6 

SMART

  

PROSITE

  

PRINTS