CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017941
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ganglioside-induced differentiation-associated protein 1 
Protein Synonyms/Alias
 GDAP1 
Gene Name
 GDAP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
104GNTESELKKLAEENPubiquitination[1]
105NTESELKKLAEENPDubiquitination[1]
120LQEAYIAKQKRLKSKubiquitination[1]
122EAYIAKQKRLKSKLLubiquitination[1]
135LLDHDNVKYLKKILDubiquitination[1]
139DNVKYLKKILDELEKubiquitination[1]
146KILDELEKVLDQVETubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Regulates the mitochondrial network by promoting mitochondrial fission. 
Sequence Annotation
 DOMAIN 24 105 GST N-terminal.
 DOMAIN 153 309 GST C-terminal.
 REGION 320 358 Required for mitochondrial localization.
 MOD_RES 203 203 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Charcot-Marie-Tooth disease; Coiled coil; Complete proteome; Cytoplasm; Disease mutation; Membrane; Mitochondrion; Mitochondrion outer membrane; Neuropathy; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 358 AA 
Protein Sequence
MRLNSTGEVP VLIHGENIIC EATQIIDYLE QTFLDERTPR LMPDKESMYY PRVQHYRELL 60
DSLPMDAYTH GCILHPELTV DSMIPAYATT RIRSQIGNTE SELKKLAEEN PDLQEAYIAK 120
QKRLKSKLLD HDNVKYLKKI LDELEKVLDQ VETELQRRNE ETPEEGQQPW LCGESFTLAD 180
VSLAVTLHRL KFLGFARRNW GNGKRPNLET YYERVLKRKT FNKVLGHVNN ILISAVLPTA 240
FRVAKKRAPK VLGTTLVVGL LAGVGYFAFM LFRKRLGSMI LAFRPRPNYF 290 
Gene Ontology
 GO:0031307; C:integral to mitochondrial outer membrane; IDA:UniProtKB.
 GO:0000266; P:mitochondrial fission; IDA:UniProtKB.
 GO:0006626; P:protein targeting to mitochondrion; IMP:UniProtKB.
 GO:0032526; P:response to retinoic acid; IEA:Compara. 
Interpro
 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR012336; Thioredoxin-like_fold. 
Pfam
  
SMART
  
PROSITE
 PS50405; GST_CTER
 PS50404; GST_NTER 
PRINTS