| Tag | Content |
|---|
| CPLM ID | CPLM-015831 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-binding cassette sub-family G member 2 |
Protein Synonyms/Alias | Breast cancer resistance protein 1 homolog; CD338 |
Gene Name | Abcg2 |
Gene Synonyms/Alias | Abcp; Bcrp1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 165 | ERINTIIKELGLEKV | ubiquitination | [1] | | 171 | IKELGLEKVADSKVG | ubiquitination | [1] | | 176 | LEKVADSKVGTQFIR | ubiquitination | [1] | | 358 | QLPGAQEKKGTSAFK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux (By similarity). May play a role in early stem cell self-renewal by blocking differentiation. |
Sequence Annotation | DOMAIN 48 285 ABC transporter.
DOMAIN 389 653 ABC transmembrane type-2.
NP_BIND 79 86 ATP (Potential).
CARBOHYD 596 596 N-linked (GlcNAc...) (Potential).
CARBOHYD 600 600 N-linked (GlcNAc...) (Potential).
DISULFID 592 610 By similarity.
DISULFID 603 603 Interchain (By similarity). |
Keyword | ATP-binding; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 657 AA |
Protein Sequence | MSSSNDHVLV PMSQRNNNGL PRTNSRAVRT LAEGDVLSFH HITYRVKVKS GFLVRKTVEK 60
EILSDINGIM KPGLNAILGP TGGGKSSLLD VLAARKDPKG LSGDVLINGA PQPAHFKCCS 120
GYVVQDDVVM GTLTVRENLQ FSAALRLPTT MKNHEKNERI NTIIKELGLE KVADSKVGTQ 180
FIRGISGGER KRTSIGMELI TDPSILFLDE PTTGLDSSTA NAVLLLLKRM SKQGRTIIFS 240
IHQPRYSIFK LFDSLTLLAS GKLVFHGPAQ KALEYFASAG YHCEPYNNPA DFFLDVINGD 300
SSAVMLNREE QDNEANKTEE PSKGEKPVIE NLSEFYINSA IYGETKAELD QLPGAQEKKG 360
TSAFKEPVYV TSFCHQLRWI ARRSFKNLLG NPQASVAQLI VTVILGLIIG AIYFDLKYDA 420
AGMQNRAGVL FFLTTNQCFS SVSAVELFVV EKKLFIHEYI SGYYRVSSYF FGKVMSDLLP 480
MRFLPSVIFT CVLYFMLGLK KTVDAFFIMM FTLIMVAYTA SSMALAIATG QSVVSVATLL 540
MTIAFVFMML FSGLLVNLRT IGPWLSWLQY FSIPRYGFTA LQYNEFLGQE FCPGFNVTDN 600
STCVNSYAIC TGNEYLINQG IELSPWGLWK NHVALACMII IFLTIAYLKL LFLKKYS 657 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:Compara. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008559; F:xenobiotic-transporting ATPase activity; EXP:Reactome. GO:0046618; P:drug export; IEA:Compara. GO:0060136; P:embryonic process involved in female pregnancy; IEA:Compara. GO:0051593; P:response to folic acid; IEA:Compara. GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |