CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026578
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ADP-ribosylation factor-binding protein GGA1 
Protein Synonyms/Alias
 GGA1 protein 
Gene Name
 GGA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23RATNPLNKELDWASIubiquitination[1]
118LIKVVSPKYLGSRTSubiquitination[1, 2, 3]
158EAYQMLKKQGIVKSDubiquitination[1]
182PLPPPRPKNVIFEDEubiquitination[1, 3, 4]
191VIFEDEEKSKMLARLubiquitination[1]
200KMLARLLKSSHPEDLubiquitination[1]
215RAANKLIKEMVQEDQubiquitination[1]
223EMVQEDQKRMEKISKubiquitination[1]
463SQQVRWEKQQPTPRLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 656 AA 
Protein Sequence
MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL LAHKIQSPQE 60
WEAIQALTVR RGEATIRPPP CDDTKVLETC MKSCGKRFHD EVGKFRFLNE LIKVVSPKYL 120
GSRTSEKVKN KILELLYSWT VGLPEEVKIA EAYQMLKKQG IVKSDPKLPD DTTFPLPPPR 180
PKNVIFEDEE KSKMLARLLK SSHPEDLRAA NKLIKEMVQE DQKRMEKISK RVNAIEEVNN 240
NVKLLTEMVM SHSQGGAAAG SSEDLMKELY QRCERMRPTL FRLASDTEDN DEALAEILQA 300
NDNLTQVINL YKQLVRGEEV NGDATAGSIP GSTSALLDLS GLDLPPAGTT YPAMPTRPGE 360
QASPEQPSAS VSLLDDELMS LGLSDPTPPS GPSLDGTGWN SFQSSDATEP PAPALAQAPS 420
MESRPPAQTS LPASSGLDDL DLLGKTLLQQ SLPPESQQVR WEKQQPTPRL TLRDLQNKSS 480
SCSSPSSSAT SLLHTVSPEP PRPPQQPVPT ELSLASITVP LESIKPSNIL PVTVYDQHGF 540
RILFHFARDP LPGRSDVLVV VVSMLSTAPQ PIRNIVFQSA VPKVMKVKLQ PPSGTELPAF 600
NPIVHPSAIT QVLLLANPQK EKVRLRYKLT FTMGDQTYNE MGDVDQFPPP ETWGSL 656 
Gene Ontology
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:InterPro. 
Interpro
 IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
 IPR008153; Clathrin_g-adaptin_app.
 IPR013041; Coatomer/clathrin_app_Ig-like.
 IPR008942; ENTH_VHS.
 IPR004152; GAT.
 IPR002014; VHS.
 IPR018205; VHS_subgr. 
Pfam
 PF02883; Alpha_adaptinC2
 PF03127; GAT
 PF00790; VHS 
SMART
 SM00809; Alpha_adaptinC2
 SM00288; VHS 
PROSITE
 PS50180; GAE
 PS50909; GAT
 PS50179; VHS 
PRINTS