UniProt Accession

 HSBP1_HUMAN; O75506; Q53XA8; Q7Z5Z3 

Genbank Protein ID

 AF068754; AY320409; BX537440; BC007515 

Genbank Nucleotide ID

 AAC25186.1; AAP73809.1; CAD97682.1; AAH07515.1 

Protein Name

 Heat shock factor-binding protein 1 

Protein Synonyms/Alias

 Nasopharyngeal carcinoma-associated antigen 13; NPC-A-13 

Gene Name

 HSBP1 

Gene Synonyms/Alias

 HSF1BP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
50	SRIDDLEKNIADLMT	ubiquitination	[1, 2]
69	EELESENKIPATQKS	ubiquitination	[1, 2]
75	NKIPATQKS******	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 76 AA 

Protein Sequence

Gene Ontology

 GO:0005856; C:cytoskeleton; IEA:Compara.
 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0006936; P:muscle contraction; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR009643; HS1-bd. 

Pfam

 PF06825; HSBP1 

SMART

  

PROSITE

  

PRINTS