CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019711
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 26S proteasome non-ATPase regulatory subunit 1 
Protein Synonyms/Alias
 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112 
Gene Name
 PSMD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
20DEDEPQLKEFALHKLubiquitination[1]
110KCIDHYTKQCVENADubiquitination[1]
136RLEGIVNKMFQRCLDubiquitination[1]
292GTVPGSEKDSDSMETubiquitination[1]
302DSMETEEKTSSAFVGubiquitination[1]
310TSSAFVGKTPEASPEubiquitination[1]
807AVLSITAKAKKKEKEubiquitination[1]
830MEVDEAEKKEEKEKKubiquitination[1]
834EAEKKEEKEKKKEPEubiquitination[1]
859RVMPAQLKVLTMPETubiquitination[1]
903PVAAHGPKIEEEEQEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. 
Sequence Annotation
 REPEAT 403 436 PC 1.
 REPEAT 441 474 PC 2.
 REPEAT 476 510 PC 3.
 REPEAT 511 545 PC 4.
 REPEAT 547 580 PC 5.
 REPEAT 581 616 PC 6.
 REPEAT 617 649 PC 7.
 REPEAT 651 685 PC 8.
 REPEAT 686 726 PC 9.
 REPEAT 729 761 PC 10.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 273 273 Phosphothreonine.
 MOD_RES 290 290 Phosphoserine.
 MOD_RES 310 310 N6-acetyllysine.
 MOD_RES 311 311 Phosphothreonine.
 MOD_RES 315 315 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Proteasome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 953 AA 
Protein Sequence
MITSAAGIIS LLDEDEPQLK EFALHKLNAV VNDFWAEISE SVDKIEVLYE DEGFRSRQFA 60
ALVASKVFYH LGAFEESLNY ALGAGDLFNV NDNSEYVETI IAKCIDHYTK QCVENADLPE 120
GEKKPIDQRL EGIVNKMFQR CLDDHKYKQA IGIALETRRL DVFEKTILES NDVPGMLAYS 180
LKLCMSLMQN KQFRNKVLRV LVKIYMNLEK PDFINVCQCL IFLDDPQAVS DILEKLVKED 240
NLLMAYQICF DLYESASQQF LSSVIQNLRT VGTPIASVPG STNTGTVPGS EKDSDSMETE 300
EKTSSAFVGK TPEASPEPKD QTLKMIKILS GEMAIELHLQ FLIRNNNTDL MILKNTKDAV 360
RNSVCHTATV IANSFMHCGT TSDQFLRDNL EWLARATNWA KFTATASLGV IHKGHEKEAL 420
QLMATYLPKD TSPGSAYQEG GGLYALGLIH ANHGGDIIDY LLNQLKNASN DIVRHGGSLG 480
LGLAAMGTAR QDVYDLLKTN LYQDDAVTGE AAGLALGLVM LGSKNAQAIE DMVGYAQETQ 540
HEKILRGLAV GIALVMYGRM EEADALIESL CRDKDPILRR SGMYTVAMAY CGSGNNKAIR 600
RLLHVAVSDV NDDVRRAAVE SLGFILFRTP EQCPSVVSLL SESYNPHVRY GAAMALGICC 660
AGTGNKEAIN LLEPMTNDPV NYVRQGALIA SALIMIQQTE ITCPKVNQFR QLYSKVINDK 720
HDDVMAKFGA ILAQGILDAG GHNVTISLQS RTGHTHMPSV VGVLVFTQFW FWFPLSHFLS 780
LAYTPTCVIG LNKDLKVSTA VLSITAKAKK KEKEKEKKEE EKMEVDEAEK KEEKEKKKEP 840
EPNFQLLDNP ARVMPAQLKV LTMPETCRYQ PFKPLSIGGI IILKDTSEDI EELVEPVAAH 900
GPKIEEEEQE PEPPEPFEYI DD 922 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005838; C:proteasome regulatory particle; TAS:ProtInc.
 GO:0030234; F:enzyme regulator activity; IEA:InterPro.
 GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0006915; P:apoptotic process; TAS:Reactome.
 GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.
 GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.
 GO:0010467; P:gene expression; TAS:Reactome.
 GO:0016071; P:mRNA metabolic process; TAS:Reactome.
 GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.
 GO:0000209; P:protein polyubiquitination; TAS:Reactome.
 GO:0042981; P:regulation of apoptotic process; TAS:Reactome.
 GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome.
 GO:0042176; P:regulation of protein catabolic process; IEA:InterPro.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0016032; P:viral reproduction; TAS:Reactome. 
Interpro
 IPR016642; 26S_Psome_Rpn2.
 IPR002015; APC_proteasome.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold. 
Pfam
 PF01851; PC_rep 
SMART
  
PROSITE
  
PRINTS