UniProt Accession

 CD70_HUMAN; P32970; Q96J57 

Genbank Protein ID

 L08096; S69339; BC000725 

Genbank Nucleotide ID

 AAA36175.1; AAB30121.1; AAH00725.1 

Protein Name

 CD70 antigen 

Protein Synonyms/Alias

 CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD70 

Gene Name

 CD70 

Gene Synonyms/Alias

 CD27L; CD27LG; TNFSF7 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	LHGPELDKGQLRIHR	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. 

Sequence Annotation

 CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
 CARBOHYD 170 170 N-linked (GlcNAc...) (Potential).
 DISULFID 133 151 Potential.  

Keyword

 Complete proteome; Cytokine; Disulfide bond; Glycoprotein; Membrane; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005102; F:receptor binding; TAS:ProtInc.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0097191; P:extrinsic apoptotic signaling pathway; IDA:BHF-UCL.
 GO:0006955; P:immune response; IEA:InterPro. 

Interpro

 IPR006052; TNF.
 IPR021184; TNF_CS.
 IPR008983; Tumour_necrosis_fac-like_dom. 

Pfam

 PF00229; TNF 

SMART

 SM00207; TNF 

PROSITE

 PS00251; TNF_1
 PS50049; TNF_2 

PRINTS