CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039042
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Neurofilament heavy polypeptide 
Protein Synonyms/Alias
  
Gene Name
 Nefh 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
98AVAARSEKEQLQALNacetylation[1]
218AARVELQKKAQALQEacetylation[1]
336TTELEALKSTKESLEacetylation[1]
339LEALKSTKESLERQRacetylation[1]
925EKEPLTEKPKDSPGEacetylation[1]
1031GLPQEPSKPKTEKAEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Coiled coil; Complete proteome; Intermediate filament; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1064 AA 
Protein Sequence
MMSFGGADAL LGAPFAPLHG GGSLHYALSR KAGAGGTRSA AGSSSGFHSW ARTSVSSVSA 60
SPSRFRGAGA ASSTDSLDTL SNGPEGCVVA AVAARSEKEQ LQALNDRFAG YIDKVRQLEA 120
HNRSLEGEAA ALRQQQAGRA AMGELYEREV REMRGAVLRL GAARGQLRLE QEHLLEDIAH 180
VRQRLDEEAR QREEAEAAAR ALARFAQEAE AARVELQKKA QALQEECGYL RRHHQEEVGE 240
LLGQIQGCGA AQAQAQAEAR DALKCDVTSA LREIRAQLEG HTVQSTLQSE EWFRVRLDRL 300
SEAAKVNTDA MRSAQEEITE YRRQLQARTT ELEALKSTKE SLERQRSELE DRHQVDMASY 360
QDAIQQLDNE LRNTKWEMAA QLREYQDLLN VKMALDIEIA AYRKLLEGEE CRIGFGPSPF 420
SLTEGLPKIP SMSTHIKVKS EEKIKVVEKS EKETVIVEEQ TEEIQVTEEV TEEEDKEAQG 480
EEEEEAEEGG EEAATTSPPA EEAASPEKET KSPVKEEAKS PAEAKSPAEA KSPAEAKSPA 540
EVKSPAVAKS PAEVKSPAEV KSPAEAKSPA EAKSPAEVKS PATVKSPGEA KSPAEAKSPA 600
EVKSPVEAKS PAEAKSPASV KSPGEAKSPA EAKSPAEVKS PATVKSPVEA KSPAEVKSPV 660
TVKSPAEAKS PVEVKSPASV KSPSEAKSPA GAKSPAEAKS PVVAKSPAEA KSPAEAKPPA 720
EAKSPAEAKS PAEAKSPAEA KSPAEAKSPV EVKSPEKAKS PVKEGAKSLA EAKSPEKAKS 780
PVKEEIKPPA EVKSPEKAKS PMKEEAKSPE KAKTLDVKSP EAKTPAKEEA KRPADIRSPE 840
QVKSPAKEEA KSPEKEETRT EKVAPKKEEV KSPVEEVKAK EPPKKVEEEK TPATPKTEVK 900
ESKKDEAPKE AQKPKAEEKE PLTEKPKDSP GEAKKEEAKE KKAAAPEEET PAKLGVKEEA 960
KPKEKAEDAK AKEPSKPSEK EKPKKEEVPA APEKKDTKEE KTTESKKPEE KPKMEAKAKE 1020
EDKGLPQEPS KPKTEKAEKS SSTDQKDSQP SEKAPEDKAA KGDK 1064 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005883; C:neurofilament; IEA:Compara.
 GO:0045110; P:intermediate filament bundle assembly; IEA:Compara.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara.
 GO:0060052; P:neurofilament cytoskeleton organization; IEA:Compara. 
Interpro
 IPR010790; DUF1388.
 IPR016044; F.
 IPR018039; Intermediate_filament_CS. 
Pfam
 PF07142; DUF1388
 PF00038; Filament 
SMART
  
PROSITE
 PS00226; IF 
PRINTS