CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000648
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Small G protein signaling modulator 2 
Protein Synonyms/Alias
 RUN and TBC1 domain-containing protein 1 
Gene Name
 SGSM2 
Gene Synonyms/Alias
 KIAA0397; RUTBC1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
590YKFGMSKKEMEQVDAacetylation[1]
611QQVLAEWKACEVVVRacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 DOMAIN 34 191 RUN.
 DOMAIN 566 939 Rab-GAP TBC.  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1006 AA 
Protein Sequence
MGSAEDAVKE KLLWNVKKEV KQIMEEAVTR KFVHEDSSHI IALCGAVEAC LLHQLRRRAA 60
GFLRSDKMAA LFTKVGKTCP VAGEICHKVQ ELQQQAEGRK PSGVSQEALR RQGSASGKAP 120
ALSPQALKHV WVRTALIEKV LDKVVQYLAE NCSKYYEKEA LLADPVFGPI LASLLVGPCA 180
LEYTKLKTAD HYWTDPSADE LVQRHRIRGP PTRQDSPAKR PALGIRKRHS SGSASEDRLA 240
ACARECVESL HQNSRTRLLY GKNHVLVQPK EDMEAVPGYL SLHQSAESLT LKWTPNQLMN 300
GTLGDSELEK SVYWDYALVV PFSQVVCIHC HQQKSGGTLV LVSQDGIQRP PLHFPQGGHL 360
LSFLSCLENG LLPRGQLEPP LWTQQGKGKV FPKLRKRSSI RSVDMEEMGT GRATDYVFRI 420
IYPGHRHEHN AGDMIEMQGF GPSLPAWHLE PLCSQGSSCL SCSSSSSPHA TPSHCSCIPD 480
RLPLRLLCES MKRQIVSRAF YGWLAHCRHL STVRTHLSAL VHHSVIPPDR PPGASAGLTK 540
DVWSKYQKDK KNYKELELLR QVYYGGIEHE IRKDVWPFLL GHYKFGMSKK EMEQVDAVVA 600
ARYQQVLAEW KACEVVVRQR EREAHPATRT KFSSGSSIDS HVQRLIHRDS TISNDVFISV 660
DDLEPPEPQD PEDSRPKPEQ EAGPGTPGTA VVEQQHSVEF DSPDSGLPSS RNYSVASGIQ 720
SSLDEGQSVG FEEEDGGGEE GSSGPGPAAH TLREPQDPSQ EKPQAGELEA GEELAAVCAA 780
AYTIELLDTV ALNLHRIDKD VQRCDRNYWY FTPPNLERLR DVMCSYVWEH LDVGYVQGMC 840
DLLAPLLVTL DNDQLAYSCF SHLMKRMSQN FPNGGAMDTH FANMRSLIQI LDSELFELMH 900
QNGDYTHFYF CYRWFLLDFK RELLYEDVFA VWEVIWAARH ISSEHFVLFI ALALVEAYRE 960
IIRDNNMDFT DIIKFFNERA EHHDAQEILR IARDLVHKVQ MLIENK 1006 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR000195; Rab-GTPase-TBC_dom.
 IPR004012; Run. 
Pfam
 PF00566; RabGAP-TBC
 PF02759; RUN 
SMART
 SM00593; RUN
 SM00164; TBC 
PROSITE
 PS50826; RUN
 PS50086; TBC_RABGAP 
PRINTS