CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038409
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mothers against decapentaplegic homolog 2 
Protein Synonyms/Alias
  
Gene Name
 Smad2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
390TIRMSFVKGWGAEYRacetylation[1, 2, 3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 434 AA 
Protein Sequence
MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE 60
LEKAITTQNC NTKCVTIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELKAIENCE 120
YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEILTEL PPLDDYTHSI PENTNFPAGI 180
EPQSNYIPET PPPGYISEDG ETSDQQLNQS MDTGSPAELS PTTLSPVNHS LDLQPVTYSE 240
PAFWCSIAYY ELNQRVGETF HASQPSLTVD GFTDPSNSER FCLGLLSNVN RNATVEMTRR 300
HIGRGVRLYY IGGEVFAECL SDSAIFVQSP NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF 360
AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK GWGAEYRYDS PVQVSTFSTV IIFILFFVSS 420
VVHVCLFSTD LYIK 434 
Gene Ontology
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003690; F:double-stranded DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO:0045165; P:cell fate commitment; IMP:MGI.
 GO:0007182; P:common-partner SMAD protein phosphorylation; ISO:MGI.
 GO:0048589; P:developmental growth; IGI:MGI.
 GO:0048701; P:embryonic cranial skeleton morphogenesis; IGI:MGI.
 GO:0048617; P:embryonic foregut morphogenesis; IGI:MGI.
 GO:0009880; P:embryonic pattern specification; IGI:MGI.
 GO:0001706; P:endoderm formation; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0030073; P:insulin secretion; IGI:MGI.
 GO:0035556; P:intracellular signal transduction; IDA:MGI.
 GO:0030324; P:lung development; IGI:MGI.
 GO:0001707; P:mesoderm formation; IMP:MGI.
 GO:0035265; P:organ growth; IGI:MGI.
 GO:0031016; P:pancreas development; IGI:MGI.
 GO:0048340; P:paraxial mesoderm morphogenesis; IMP:MGI.
 GO:0060039; P:pericardium development; IGI:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0009791; P:post-embryonic development; IGI:MGI.
 GO:0051098; P:regulation of binding; IDA:MGI.
 GO:0009749; P:response to glucose stimulus; IGI:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:MGI. 
Interpro
 IPR013790; Dwarfin.
 IPR003619; MAD_homology1_Dwarfin-type.
 IPR013019; MAD_homology_MH1.
 IPR017855; SMAD_dom-like.
 IPR001132; SMAD_dom_Dwarfin-type.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF03165; MH1
 PF03166; MH2 
SMART
 SM00523; DWA
 SM00524; DWB 
PROSITE
 PS51075; MH1
 PS51076; MH2 
PRINTS