UniProt Accession

 CPXR_ECOLI; P0AE88; P16244; P76777; Q2M8K9 

Genbank Protein ID

 L14579; L19201; U00096; AP009048; X13307; M36795 

Genbank Nucleotide ID

 AAC36868.1; AAB03045.1; AAC76894.1; BAE77397.1; CAA31686.1; AAA23599.1 

Protein Name

 Transcriptional regulatory protein CpxR 

Protein Synonyms/Alias

  

Gene Name

 cpxR 

Gene Synonyms/Alias

 yiiA; b3912; JW3883 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
57	LDVMMPKKNGIDTLK	acetylation	[1]
64	KNGIDTLKALRQTHQ	acetylation	[1]
100	GADDYLPKPFNDREL	acetylation	[1]
188	LSQEVLGKRLTPFDR	acetylation	[1]
219	KDGHPWFKTLRGRGY	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein. 

Sequence Annotation

 DOMAIN 1 115 Response regulatory.
 MOD_RES 51 51 4-aspartylphosphate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 232 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc.
 GO:0035556; P:intracellular signal transduction; IEA:GOC.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR001867; Sig_transdc_resp-reg_C.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00072; Response_reg
 PF00486; Trans_reg_C 

SMART

 SM00448; REC
 SM00862; Trans_reg_C 

PROSITE

 PS50110; RESPONSE_REGULATORY 

PRINTS