CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021460
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 552 
Protein Synonyms/Alias
  
Gene Name
 ZNF552 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
158VEEALFAKRCKLHVSubiquitination[1]
198HTGKSNSKTECVSLFubiquitination[1]
251ECGKSSSKYDSFSNHubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 14 90 KRAB.
 ZN_FING 91 113 C2H2-type 1.
 ZN_FING 119 141 C2H2-type 2; degenerate.
 ZN_FING 212 234 C2H2-type 3; degenerate.
 ZN_FING 244 262 C2H2-type 4; degenerate.
 ZN_FING 268 290 C2H2-type 5.
 ZN_FING 296 318 C2H2-type 6.
 ZN_FING 324 346 C2H2-type 7.
 ZN_FING 352 374 C2H2-type 8.
 ZN_FING 380 402 C2H2-type 9.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 407 AA 
Protein Sequence
MAAAALRFPV QGTVTFEDVA VKFTQEEWNL LSEAQRCLYR DVTLENLALM SSLGCWCGVE 60
DEAAPSKQSI YIQRETQVRT PMAGVSPKKA HPCEMCGPIL GDILHVADHQ GTHHKQKLHR 120
CEAWGNKLYD SGNFHQHQNE HIGEKPYRGS VEEALFAKRC KLHVSGESSV FSESGKDFLL 180
RSGLLQQEAT HTGKSNSKTE CVSLFHGGKS HYSCGGCMKH FSTKDILSQH ERLLPTEEPS 240
VWCECGKSSS KYDSFSNHQG VHTREKPYTC GICGKLFNSK SHLLVHQRIH TGEKPYECEV 300
CQKFFRHKYH LIAHQRVHTG ERPYECSDCG KSFTHSSTFR VHKRVHTGQK PYECSECGKS 360
FAESSSLTKH RRVHTGEKPY GCSECEKKFR QISSLRHHQR VHKRKGL 407 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS