UniProt Accession

 B4DGW1_HUMAN; B4DGW1 

Genbank Protein ID

 AC011452; AK294802 

Genbank Nucleotide ID

 BAG57922.1 

Protein Name

 Inactive serine/threonine-protein kinase VRK3 

Protein Synonyms/Alias

 cDNA FLJ53987, highly similar to Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) 

Gene Name

 VRK3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	SALDVSPKHVLSERS	acetylation	[1]
44	SALDVSPKHVLSERS	ubiquitination	[2, 3]
107	FRYCPSGKHVAYVEG	ubiquitination	[3]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 243 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004672; F:protein kinase activity; IEA:InterPro. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom. 

Pfam

 PF00069; Pkinase 

SMART

  

PROSITE

 PS50011; PROTEIN_KINASE_DOM 

PRINTS