CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040568
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Iqgap3 
Protein Synonyms/Alias
  
Gene Name
 Iqgap3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
908IKIGLLVKNRITLQEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1632 AA 
Protein Sequence
MEPCAAGRAR TAYERLTAEE MDEQRRQNVA YQYLCRLEEA KRWMEVCLKE ELPSPVELEE 60
SLRNGVLLAK LGHCFAPSVV PLKKIYDVEQ LRYQATGLHF RHTDNINFWL SAVAHIGLPS 120
IFLPETTDIY DKKNMPRVIY CIHALSLFLF RLGLAPQIHD LYGKVKFTAE ELGNIASELA 180
KYGLQLPAFS KIGGILANEF SADEAAVHAA ILAINDAVER GVVEDTLVTL QNPNALLGNL 240
REPLAAVYQE LLALAKMEKA ANARNHDDGQ EQDIYESCLT QAEIQGHINL ANVQGALEVV 300
DDALERQNPG ALLEALHDPV LALQGVRGTF ADWYLEQLTS DREQKSQELG LVRLLEKEEI 360
QAGVAVANEK GDEEQTMLQA VWRINKAIRR GVAADTVKEL MCPEAQLPRV YPFASAFYQQ 420
ELALLQKQQQ GELGQEELFV AVEMLSAVVL INRALEAGDV CAFWDNLVNP ATGLAQVEEE 480
NAQRYFDALV KVQQFQGTHR GILSWNDLQA AVSQVNEQVQ EETDQVLAIS LINEALDQGC 540
PEKTLSALLL PAAGLEDVSL HVAPRYHLLL VAAKRQKARV TGDPGAVLWL EEIRQGVARA 600
NEDTSTAQRI ALGVAAINQA IKEGKAAQTE RVLRNPNVAL RGIVPDCAKS YQQALEGAAA 660
KKQCPGDTAF WVQHDMKDGT AYYLHLQTFQ GTWEHPSGCH LNTSHLTWEE IQSVITKVTA 720
AHDRQLLWKA NVGFVIKLQA RLRGFLVRQK FAESSHVFRT LLPAVIKIQA HWRGYRQRKA 780
YQERLQHFKA NLDAIIKIQA WARMWAARRR YLRRLRYFQK NVDSVVKIQA FFRARKARDD 840
YRMLVHARHP PLCVVRKFAH LLNQSQEDFS AESELLKLQE EVVRKIRSNQ QLEQDLNLMD 900
IKIGLLVKNR ITLQEVVSHC KKLTKKNKEQ LSDMMILDKQ KGLKSLSREK RQKLEAYQHL 960
FYLLQTQPIY LAKLIFQMPQ NKTTKFMEGV IFSLYNYASN RREAYLLLQL FRTALQEEIK 1020
SKVEQPQDVV TGNPTVVRLV VRFYRNGRGQ SALQEILGKV IQDVLEDRSV SIHTDPVHIY 1080
KSWINQEEAQ TGQRSHLPYD VTPEQALSHS EVQRRLDISL RSLLTLTEKF FVAISSSVDH 1140
IPYGMRYMAK VLKTTLEKKF PNATERDIYK VVGNLLYYRF LNPAVVAPDA FDIVAMAAGS 1200
TLAAPQRHAL GAVAQLLQHA AAGQIFSGES RHLRVLNDYL EDLHLKFRKF ICRACRVPEP 1260
EERFAIDEYS DMVAVAKPMV YITVGELIGT HRLLLEHQDQ LAPGHQDPLH QLLEDLGEPP 1320
TISDLIGDNI ATDGHVDLSR LEVSLTLTNK FEGLETDADH NSNQSLLLST KQMLADLIQF 1380
HPGESLEEIL TSSAPREHEE AHRRLMCWRQ ACDTQKPEPL RRHHSLMAHS LLSLSEKQQR 1440
VLRNLRRLQG LGLVRASDCY QGLVDELAKD ICNQRRHRQR RKAEMLRLRT TLQGLDAKTI 1500
FYEEQGDYYN QYIQACLDHL APKPKSSGKG KKQPSLHYTA AQLLEKGVLV EIEDLPVSHF 1560
RNVIFDITPG DEAGRFFVNA KFLGVDMEKF QLHYQDLLQL QYEGVAVMKL FNKAKVNVNL 1620
LIFLLNKKFL RK 1632 
Gene Ontology
 GO:0005911; C:cell-cell junction; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0016328; C:lateral plasma membrane; IDA:MGI.
 GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
 GO:0000187; P:activation of MAPK activity; IMP:MGI.
 GO:0071310; P:cellular response to organic substance; IDA:MGI.
 GO:0070371; P:ERK1 and ERK2 cascade; IMP:MGI.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:MGI.
 GO:0010629; P:negative regulation of gene expression; IMP:MGI.
 GO:0010628; P:positive regulation of gene expression; IMP:MGI.
 GO:0033601; P:positive regulation of mammary gland epithelial cell proliferation; IMP:MGI.
 GO:0032320; P:positive regulation of Ras GTPase activity; IEA:GOC.
 GO:0007265; P:Ras protein signal transduction; IMP:MGI.
 GO:0008361; P:regulation of cell size; IMP:MGI. 
Interpro
 IPR001715; CH-domain.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027417; P-loop_NTPase.
 IPR001936; RasGAP.
 IPR000593; RasGAP_C.
 IPR023152; RasGAP_CS.
 IPR008936; Rho_GTPase_activation_prot.
 IPR001202; WW_dom. 
Pfam
 PF00307; CH
 PF00612; IQ
 PF00616; RasGAP
 PF03836; RasGAP_C 
SMART
 SM00033; CH
 SM00015; IQ
 SM00323; RasGAP 
PROSITE
 PS50021; CH
 PS50096; IQ
 PS00509; RAS_GTPASE_ACTIV_1
 PS50018; RAS_GTPASE_ACTIV_2
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS