CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032024
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heterogeneous nuclear ribonucleoprotein U-like protein 1 
Protein Synonyms/Alias
 cDNA FLJ56481, highly similar to Heterogeneous nuclear ribonucleoprotein U-like protein 1 
Gene Name
 HNRNPUL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
28FYDTQVIKQENESGYubiquitination[1, 2, 3]
57PEMKTEMKQGAPTSFubiquitination[1]
73PPEASQLKPDRQQFQacetylation[4]
73PPEASQLKPDRQQFQubiquitination[2, 3, 5]
181INEEISVKHLPSTEPubiquitination[1, 3, 5]
221GYGGTGKKSTNSRFEubiquitination[3]
261LSFTKNGKWMGIAFRubiquitination[3]
329GTVGPKSKAECEILMubiquitination[3]
351GKTTWAIKHAASNPSubiquitination[1, 3, 5]
372GTNAIMDKMRVMGLRubiquitination[3, 6]
428YGSAQRRKMRPFEGFubiquitination[3, 5]
438PFEGFQRKAIVICPTubiquitination[3, 5, 6]
450CPTDEDLKDRTIKRTubiquitination[3, 5]
462KRTDEEGKDVPDHAVacetylation[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Ribonucleoprotein; Viral nucleoprotein; Virion. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 767 AA 
Protein Sequence
MRSWAFSYLD AMDNITRQNQ FYDTQVIKQE NESGYERRPL EMEQQQAYRP EMKTEMKQGA 60
PTSFLPPEAS QLKPDRQQFQ SRKRPYEENR GRGYFEHRED RRGRSPQPPA EEDEDDFDDT 120
LVAIDTYNCD LHFKVARDRS SGYPLTIEGF AYLWSGARAS YGVRRGRVCF EMKINEEISV 180
KHLPSTEPDP HVVRIGWSLD SCSTQLGEEP FSYGYGGTGK KSTNSRFENY GDKFAENDVI 240
GCFADFECGN DVELSFTKNG KWMGIAFRIQ KEALGGQALY PHVLVKNCAV EFNFGQRAEP 300
YCSVLPGFTF IQHLPLSERI RGTVGPKSKA ECEILMMVGL PAAGKTTWAI KHAASNPSKK 360
YNILGTNAIM DKMRVMGLRR QRNYAGRWDV LIQQATQCLN RLIQIAARKK RNYILDQTNV 420
YGSAQRRKMR PFEGFQRKAI VICPTDEDLK DRTIKRTDEE GKDVPDHAVL EMKANFTLPD 480
VGDFLDEVLF IELQREEADK LVRQYNEEGR KAGPPPEKRF DNRGGGGFRG RGGGGGFQRY 540
ENRGPPGGNR GGFQNRGGGS GGGGNYRGGF NRSGGGGYSQ NRWGNNNRDN NNSNNRGSYN 600
RAPQQQPPPQ QPPPPQPPPQ QPPPPPSYSP ARNPPGASTY NKNSNIPGSS ANTSTPTVSS 660
YSPPQPSYSQ PPYNQGGYSQ GYTAPPPPPP PPPAYNYGSY GGYNPAPYTP PPPPTAQTYP 720
QPSYNQYQQY AQQWNQYYQN QGQWPPYYGN YDYGSYSGNT QGGTSTQ 767 
Gene Ontology
 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:UniProtKB-KW.
 GO:0009615; P:response to virus; IEA:InterPro.
 GO:0006396; P:RNA processing; IEA:InterPro. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR027025; hnRNP_U_like_1.
 IPR027417; P-loop_NTPase.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF00622; SPRY 
SMART
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY 
PRINTS