CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032429
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Malate dehydrogenase, cytoplasmic 
Protein Synonyms/Alias
  
Gene Name
 MDH1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18TNCLTASKSAPSIPKubiquitination[1, 2]
25KSAPSIPKENFSCLTubiquitination[1]
40RLDHNRAKAQIALKLubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 210 AA 
Protein Sequence
MVIVVGNPAN TNCLTASKSA PSIPKENFSC LTRLDHNRAK AQIALKLGVT ANDVKNVIIW 60
GNHSSTQYPD VNHAKVKLQG KEVGVYEALK DDSWLKGEFV TTVQQRGAAV IKARKLSSAM 120
SAAKAICDHV RDIWFGTPEG EFVSMGVISD GNSYGVPDDL LYSFPVVIKN KTWKFVEGLP 180
INDFSREKMD LTAKELTEEK ESAFEFLSSA 210 
Gene Ontology
 GO:0016615; F:malate dehydrogenase activity; IEA:InterPro.
 GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
 GO:0006108; P:malate metabolic process; IEA:InterPro. 
Interpro
 IPR022383; Lactate/malate_DH_C.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR001252; Malate_DH_AS.
 IPR010945; Malate_DH_type2.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02866; Ldh_1_C 
SMART
  
PROSITE
 PS00068; MDH 
PRINTS