| Tag | Content |
|---|
| CPLM ID | CPLM-000536 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sphingomyelin phosphodiesterase 3 |
Protein Synonyms/Alias | Confluent 3Y1 cell-associated protein 1; Neutral sphingomyelinase 2; nSMase-2; nSMase2; Neutral sphingomyelinase II |
Gene Name | Smpd3 |
Gene Synonyms/Alias | Cca1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 45 | FIPTTYEKRQRADDP | ubiquitination | [1] | | 103 | SYSRLEDKSPAGGAA | ubiquitination | [1] | | 116 | AALLSEWKGTGAGKS | ubiquitination | [1] | | 586 | YLAFPTSKSPGAGQK | ubiquitination | [1] | | 600 | KGRKDLLKGNGRRID | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF- kappa-B activation under inflammatory conditions. |
Sequence Annotation | ACT_SITE 639 639 Proton acceptor (By similarity).
METAL 362 362 Magnesium (By similarity).
LIPID 53 53 S-palmitoyl cysteine (By similarity).
LIPID 59 59 S-palmitoyl cysteine (By similarity).
LIPID 395 395 S-palmitoyl cysteine (By similarity).
LIPID 396 396 S-palmitoyl cysteine (By similarity). |
Keyword | Cell cycle; Cell membrane; Complete proteome; Developmental protein; Golgi apparatus; Hydrolase; Lipid metabolism; Lipoprotein; Magnesium; Membrane; Metal-binding; Palmitate; Reference proteome; Sphingolipid metabolism. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 655 AA |
Protein Sequence | MVLYTTPFPN SCLSALHAVS WALIFPCYWL VDRLVASFIP TTYEKRQRAD DPCYLQLFCT 60
VLFTPVYLAL LVAALPFAFL GFIFWSPLQS ARRPYSYSRL EDKSPAGGAA LLSEWKGTGA 120
GKSFCFATAN VCLLPDSLAR LNNVFNTQAR AKEIGQRIRN GAARPQIKIY IDSPTNTSIS 180
AASFSSLVSP QGSDGARAVP GSIKRTASVE YKGDGGRHPS DEAANGPASG EQADGSLEDS 240
CIVRIGGEEG GRAQEADDPA PGSQARNGAG GTPKGQTPNH NQRDGDSGSL GSPSASRESL 300
VKARAGQDSG GSGEPGSNSK LLYKTSVVKK AAARRRRHPD EAFDHEVSAF FPANLDFLCL 360
QEVFDKRAAA KLKEQLHGYF EYILYDVGVY GCHGCCNFKC LNSGLFFASR YPVMDVAYHC 420
YPNGCSFDAL ASKGALFLKV QVGSTPQDQR IVGYIACTHL HAPPEDSAIR CEQLDLLQDW 480
LADFRKSTSS TSTANPEELV VFDVICGDLN FDNCSSDDKL EQQHSLFTRY KDPCRLGPGE 540
EKPWAIGTLL DINGLYDEDV CTPDNLQKVL ESEEGRREYL AFPTSKSPGA GQKGRKDLLK 600
GNGRRIDYML HAEEGLCPDW KAEVEEFSFI TQLSGLTDHL PVAMRLMVSA GEEEA 655 |
Gene Ontology | GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |