CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043174
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho guanine nucleotide exchange factor 2 
Protein Synonyms/Alias
 Rho/rac guanine nucleotide exchange factor (GEF) 2, isoform CRA_b 
Gene Name
 Arhgef2 
Gene Synonyms/Alias
 mCG_8844 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
339TKALKLYKELYARDKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 970 AA 
Protein Sequence
MTGRDKTREK EKMKEAKDAR YTNGHLFTTI SVSGMTMCYA CNKSITAKEA LICPTCNVTI 60
HNRCKDTLAN CTKVKQKQQK AALLRNNTAL QSVSLRSKTT TRERPTSAIY PSDSFRQSLL 120
GSRRGLSSLS LAKSVSTTNI AGHFNDESPL GLRQILSQST DSLNMRNRTL SVESLIDEGV 180
EVFYNELMSD FEMDEKDFEA DSWSLAVDSS FLQQHKKEVM KKQDVIYELI QTELHHVRTL 240
KIMTRLFRTG MLEELQMEPE VVQGLFPCVD ELSDIHTRFL NQLLERRRQA LCPGSTRNFV 300
IHRLGDLLIS QFSGSNAEQM RKTYSEFCSR HTKALKLYKE LYARDKRFQQ FIRKMTRSAV 360
LKRHGVQECI LLVTQRITKY PVLINRILQN SHGVEEEYQD LASALGLVKE LLSNVDQDVH 420
ELEKEARLQE IYNRMDPRAQ TPVPGKGPFG RDELLRRKLI HEGCLLWKTA TGRFKDVLLL 480
LMTDVLVFLQ EKDQKYIFTS LDKPSVVSLQ NLIVRDIANQ AKGMFLISSG PPEMYEVHAA 540
SRDDRTTWIR VIQQSVRLCP SREDFPLIET EDKAYLRRIK TKLQQKNQAL VELLQKNVEL 600
FAEMVHFQAL KAGFVGMPPP ALPRGLFRLE SFESLRGERL LKDALREVEG LKDLLLGPCV 660
DLPMTSREPA LPLDSDSGSC PGVTANGEAR TFNGSIELCR ADSDSSQKDR NGNQLRSPQE 720
EVLQPLINLY GLLHGLQAVV VQQERLMEAL FPEGPERWEK LSRANSRDGE AGRAAVASVT 780
PEKQATELAL LQRQHTLLQE ELRRCQRLGE ERATEAGSLE ARLRESEQAR ALLEREAEEI 840
RRQLAALGQN EPLPAEAPWA RRPLDPRRRS LPAGDALYLS FNPPQPSRGH DRLDLPVTVR 900
SLHRPFDDRE AQELGSPEDR LQDSSDPDTG SEEEVSSRLS PPHSPRDFTR MQDIPEETES 960
RDGEPTASES 970 
Gene Ontology
 GO:0043198; C:dendritic shaft; IDA:MGI.
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008017; F:microtubule binding; IDA:MGI.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:MGI.
 GO:0007015; P:actin filament organization; IPI:MGI.
 GO:0000902; P:cell morphogenesis; IDA:MGI.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IDA:MGI. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR015721; RhoGEF-like. 
Pfam
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00109; C1
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS