CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011908
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hyaluronidase-1 
Protein Synonyms/Alias
 Hyal-1; Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1 
Gene Name
 HYAL1 
Gene Synonyms/Alias
 LUCA1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
144WAFNWDTKDIYRQRSubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. 
Sequence Annotation
 DOMAIN 354 430 EGF-like.
 ACT_SITE 131 131 Proton donor (Probable).
 CARBOHYD 99 99 N-linked (GlcNAc...).
 CARBOHYD 216 216 N-linked (GlcNAc...).
 CARBOHYD 350 350 N-linked (GlcNAc...).
 DISULFID 43 333
 DISULFID 207 221
 DISULFID 358 369
 DISULFID 363 418
 DISULFID 420 429  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; EGF-like domain; Glycoprotein; Glycosidase; Hydrolase; Lysosome; Mucopolysaccharidosis; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 435 AA 
Protein Sequence
MAAHLLPICA LFLTLLDMAQ GFRGPLLPNR PFTTVWNANT QWCLERHGVD VDVSVFDVVA 60
NPGQTFRGPD MTIFYSSQLG TYPYYTPTGE PVFGGLPQNA SLIAHLARTF QDILAAIPAP 120
DFSGLAVIDW EAWRPRWAFN WDTKDIYRQR SRALVQAQHP DWPAPQVEAV AQDQFQGAAR 180
AWMAGTLQLG RALRPRGLWG FYGFPDCYNY DFLSPNYTGQ CPSGIRAQND QLGWLWGQSR 240
ALYPSIYMPA VLEGTGKSQM YVQHRVAEAF RVAVAAGDPN LPVLPYVQIF YDTTNHFLPL 300
DELEHSLGES AAQGAAGVVL WVSWENTRTK ESCQAIKEYM DTTLGPFILN VTSGALLCSQ 360
ALCSGHGRCV RRTSHPKALL LLNPASFSIQ LTPGGGPLSL RGALSLEDQA QMAVEFKCRC 420
YPGWQAPWCE RKSMW 435 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0036117; C:hyaluranon cable; IDA:UniProtKB.
 GO:0043202; C:lysosomal lumen; TAS:Reactome.
 GO:0050501; F:hyaluronan synthase activity; IDA:UniProtKB.
 GO:0004415; F:hyalurononglucosaminidase activity; IDA:UniProtKB.
 GO:0008134; F:transcription factor binding; IDA:UniProtKB.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0051216; P:cartilage development; IEP:UniProtKB.
 GO:0044344; P:cellular response to fibroblast growth factor stimulus; IDA:UniProtKB.
 GO:0071347; P:cellular response to interleukin-1; IDA:UniProtKB.
 GO:0071467; P:cellular response to pH; IDA:UniProtKB.
 GO:0036120; P:cellular response to platelet-derived growth factor stimulus; IDA:UniProtKB.
 GO:0071356; P:cellular response to tumor necrosis factor; IEP:UniProtKB.
 GO:0071493; P:cellular response to UV-B; IDA:UniProtKB.
 GO:0030207; P:chondroitin sulfate catabolic process; TAS:Reactome.
 GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Compara.
 GO:0030213; P:hyaluronan biosynthetic process; IDA:UniProtKB.
 GO:0030214; P:hyaluronan catabolic process; IDA:UniProtKB.
 GO:0006954; P:inflammatory response; IDA:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:0045766; P:positive regulation of angiogenesis; IDA:UniProtKB.
 GO:0045785; P:positive regulation of cell adhesion; IMP:UniProtKB.
 GO:0030307; P:positive regulation of cell growth; IMP:UniProtKB.
 GO:0010634; P:positive regulation of epithelial cell migration; IDA:UniProtKB.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:UniProtKB.
 GO:1900106; P:positive regulation of hyaluranon cable assembly; IDA:UniProtKB.
 GO:0046677; P:response to antibiotic; IDA:UniProtKB.
 GO:0000302; P:response to reactive oxygen species; IDA:UniProtKB.
 GO:0009615; P:response to virus; IDA:UniProtKB. 
Interpro
 IPR013785; Aldolase_TIM.
 IPR000742; EG-like_dom.
 IPR017853; Glycoside_hydrolase_SF.
 IPR018155; Hyaluronidase. 
Pfam
 PF01630; Glyco_hydro_56 
SMART
 SM00181; EGF 
PROSITE
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3 
PRINTS
 PR00846; GLHYDRLASE56.