CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039396
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 
Protein Synonyms/Alias
  
Gene Name
 Inpp5d 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
373EKEKILRKEYVFSDSacetylation[1]
431ITSWFLSKGQGKTRDacetylation[1]
435FLSKGQGKTRDDSADacetylation[1]
764SCLESFVKSQEGENEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1190 AA 
Protein Sequence
MPAMVPGWNH GNITRSKAEE LLSRAGKDGS FLVRASESIP RAYALCVLFR NCVYTYRILP 60
NEDDKFTVQA SEGVPMRFFT KLDQLIEFYK KENMGLVTHL QFPVPLEEED AIDEPEEDTE 120
SVMSPPELPP RNIPVSAGPC EAKDLPLPTE NPRAPEVTRL SLSETLFQRL QSMDTSGLPE 180
EHLKAIQDYL STQLMLDSDF LKTGSSNLPH LKKLTSLLCK ELHGEVIRTL PSLESLQRLF 240
DQQLSPGLRP RPQVPGEANP ITMVAKLSQL TSLLSSIEDK VKALLHEGSE STNRRSLIPP 300
VTFEVKSESL GIPQKMHLKV DVESGKLIIK KSRDGSEDKF YSHKKILQLI KSQKFLNKLV 360
ILVETEKEKI LRKEYVFSDS KKREGFCQLL QQMKNKHSEQ SEPDMITIFI GTWNMGNAPP 420
PKKITSWFLS KGQGKTRDDS ADYIPHDIYV IGTQEDPLGE KEWLEILRHS LQEVTSMTFK 480
TVAIHTLWNI RIVVLAKPEH ENRISHICTD NVKTGIANTL GNKGAVGVSF MFNGTSLGFV 540
NSHLTSGSEK KLRRNQNYMN ILRFLALGDK KLSPFNITHR FTHLFWLGDL NYRVELPTWE 600
AEAIIQKIKQ QQYSDLLAHD QLLLERKEQK VFLHFEEEEI TFAPTYRFER LTRDKYAYTK 660
QKATGMKYNL PSWCDRVLWK SYPLVHVVCQ SYGSTSDIMT SDHSPVFATF EAGVTSQFVS 720
KNGPGAVDSQ GQIEFLACYA TLKTKSQTKF YLELHSSCLE SFVKSQEGEN EEGDEGELVV 780
RFGETLPKLK PIISDPEYLL DQHILISIKS SDSDESYGEG CIALRLETTE SQLPIYTPLT 840
HHGEMTGHFR GEIKLQTSEG KMREKLYDFV KTERDESSGM KCLKNLTSHD PMRQWEPAGR 900
VPACGISSLN EIINPNYIGM GPFGQPLHGK STLSPDQQLT AWSYDQLPKD SSLGPGRGEG 960
PPTPPSQPPL SPKKFSSSTA NRGSCPRVQE TRPGDLGKVE ALPQEDLPLT KPEMFENPLY 1020
GSVSPFPKLV PRKEQESPKM MRKEPPPCPD PGVSSPSIML PKAQEVENVK GTSKQAPVPV 1080
FGPTPRIRSF TCSSSAEGRM PSGDKSQGKP KAPASSQAPV PVKRPVKPSR SEMSQQTTPI 1140
PAPRPPLPVK SPAVLQLQHS KGRDYRDNTE LPHHGKHRQE ESLLGRTAMQ 1190 
Gene Ontology
 GO:0005622; C:intracellular; IEA:Compara.
 GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:Compara.
 GO:0034594; F:phosphatidylinositol trisphosphate phosphatase activity; IEA:Compara.
 GO:0008340; P:determination of adult lifespan; IEA:Compara.
 GO:0016064; P:immunoglobulin mediated immune response; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:Compara.
 GO:0030889; P:negative regulation of B cell proliferation; IEA:Compara.
 GO:0045779; P:negative regulation of bone resorption; IEA:Compara.
 GO:0050777; P:negative regulation of immune response; IEA:Compara.
 GO:0045409; P:negative regulation of interleukin-6 biosynthetic process; IEA:Compara.
 GO:0045656; P:negative regulation of monocyte differentiation; IEA:Compara.
 GO:0045659; P:negative regulation of neutrophil differentiation; IEA:Compara.
 GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Compara.
 GO:0009968; P:negative regulation of signal transduction; IEA:Compara.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0045579; P:positive regulation of B cell differentiation; IEA:Compara.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Compara. 
Interpro
 IPR005135; Endo/exonuclease/phosphatase.
 IPR000300; IPPc.
 IPR000980; SH2. 
Pfam
 PF03372; Exo_endo_phos
 PF00017; SH2 
SMART
 SM00128; IPPc
 SM00252; SH2 
PROSITE
 PS50001; SH2 
PRINTS
 PR00401; SH2DOMAIN.