CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033455
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 cAMP-responsive element modulator 
Protein Synonyms/Alias
  
Gene Name
 CREM 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
274KTLIEELKALKDLYCubiquitination[1, 2, 3]
277IEELKALKDLYCHKVubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 285 AA 
Protein Sequence
MSKCARKKYI KTNPRQMTME TVESQHDGSI TASLTESKSA HVQTQTGQNS IPALAQVSVA 60
GSGTRRGSPA VTLVQLPSGQ TIHVQGVIQT PQPWVIQSSE IHTVQVAAIA ETDESAESEG 120
VIDSHKRREI LSRRPSYRKI LNELSSDVPG VPKIEEERSE EEGTPPSIAT MAVPTSIYQT 180
STGQYTATGD MPTYQIRAPT AALPQGVVMA ASPGSLHSPQ QLAEEATRKR ELRLMKNREA 240
ARECRRKKKE YVKCLENRVA VLENQNKTLI EELKALKDLY CHKVE 285 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. 
Interpro
 IPR004827; bZIP.
 IPR003102; Coactivator_CBP_pKID.
 IPR001630; Leuzip_CREB. 
Pfam
 PF00170; bZIP_1
 PF02173; pKID 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC
 PS50953; KID 
PRINTS
 PR00041; LEUZIPPRCREB.