CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004893
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrin alpha-L 
Protein Synonyms/Alias
 CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a 
Gene Name
 ITGAL 
Gene Synonyms/Alias
 CD11A 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
130FDFSDYVKRKDPDALubiquitination[1]
218ESQETLHKFASKPASubiquitination[1]
229KPASEFVKILDTFEKubiquitination[1]
246DLFTELQKKIYVIEGubiquitination[1]
288VVGAVGAKDWAGGFLubiquitination[1]
333TWLPSRQKTSLLASGubiquitination[1]
664PRDQRAGKDIPPILRubiquitination[1]
691EKNCGEDKKCEANLRubiquitination[1]
692KNCGEDKKCEANLRVubiquitination[1]
747PPGLSFRKVEMLKPHubiquitination[1]
752FRKVEMLKPHSQIPVubiquitination[1]
866GPKIHQVKHMYQVRIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. 
Sequence Annotation
 REPEAT 31 82 FG-GAP 1.
 REPEAT 83 141 FG-GAP 2.
 DOMAIN 156 327 VWFA.
 REPEAT 338 389 FG-GAP 3.
 REPEAT 390 445 FG-GAP 4.
 REPEAT 446 506 FG-GAP 5.
 REPEAT 507 563 FG-GAP 6.
 REPEAT 567 627 FG-GAP 7.
 MOTIF 1115 1119 GFFKR motif.
 CARBOHYD 65 65 N-linked (GlcNAc...) (Potential).
 CARBOHYD 89 89 N-linked (GlcNAc...) (Potential).
 CARBOHYD 188 188 N-linked (GlcNAc...).
 CARBOHYD 649 649 N-linked (GlcNAc...) (Potential).
 CARBOHYD 670 670 N-linked (GlcNAc...) (Potential).
 CARBOHYD 726 726 N-linked (GlcNAc...) (Potential).
 CARBOHYD 730 730 N-linked (GlcNAc...) (Potential).
 CARBOHYD 862 862 N-linked (GlcNAc...) (Potential).
 CARBOHYD 885 885 N-linked (GlcNAc...) (Potential).
 CARBOHYD 897 897 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1060 1060 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1071 1071 N-linked (GlcNAc...) (Potential).
 DISULFID 73 80 By similarity.
 DISULFID 111 129 By similarity.
 DISULFID 653 707 By similarity.
 DISULFID 771 777 By similarity.
 DISULFID 845 861 By similarity.
 DISULFID 998 1013 By similarity.
 DISULFID 1021 1052 By similarity.  
Keyword
 3D-structure; Alternative splicing; Calcium; Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Integrin; Magnesium; Membrane; Metal-binding; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1170 AA 
Protein Sequence
MKDSCITVMA MALLSGFFFF APASSYNLDV RGARSFSPPR AGRHFGYRVL QVGNGVIVGA 60
PGEGNSTGSL YQCQSGTGHC LPVTLRGSNY TSKYLGMTLA TDPTDGSILF AAVQFSTSYK 120
TEFDFSDYVK RKDPDALLKH VKHMLLLTNT FGAINYVATE VFREELGARP DATKVLIIIT 180
DGEATDSGNI DAAKDIIRYI IGIGKHFQTK ESQETLHKFA SKPASEFVKI LDTFEKLKDL 240
FTELQKKIYV IEGTSKQDLT SFNMELSSSG ISADLSRGHA VVGAVGAKDW AGGFLDLKAD 300
LQDDTFIGNE PLTPEVRAGY LGYTVTWLPS RQKTSLLASG APRYQHMGRV LLFQEPQGGG 360
HWSQVQTIHG TQIGSYFGGE LCGVDVDQDG ETELLLIGAP LFYGEQRGGR VFIYQRRQLG 420
FEEVSELQGD PGYPLGRFGE AITALTDING DGLVDVAVGA PLEEQGAVYI FNGRHGGLSP 480
QPSQRIEGTQ VLSGIQWFGR SIHGVKDLEG DGLADVAVGA ESQMIVLSSR PVVDMVTLMS 540
FSPAEIPVHE VECSYSTSNK MKEGVNITIC FQIKSLIPQF QGRLVANLTY TLQLDGHRTR 600
RRGLFPGGRH ELRRNIAVTT SMSCTDFSFH FPVCVQDLIS PINVSLNFSL WEEEGTPRDQ 660
RAGKDIPPIL RPSLHSETWE IPFEKNCGED KKCEANLRVS FSPARSRALR LTAFASLSVE 720
LSLSNLEEDA YWVQLDLHFP PGLSFRKVEM LKPHSQIPVS CEELPEESRL LSRALSCNVS 780
SPIFKAGHSV ALQMMFNTLV NSSWGDSVEL HANVTCNNED SDLLEDNSAT TIIPILYPIN 840
ILIQDQEDST LYVSFTPKGP KIHQVKHMYQ VRIQPSIHDH NIPTLEAVVG VPQPPSEGPI 900
THQWSVQMEP PVPCHYEDLE RLPDAAEPCL PGALFRCPVV FRQEILVQVI GTLELVGEIE 960
ASSMFSLCSS LSISFNSSKH FHLYGSNASL AQVVMKVDVV YEKQMLYLYV LSGIGGLLLL 1020
LLIFIVLYKV GFFKRNLKEK MEAGRGVPNG IPAEDSEQLA SGQEAGDPGC LKPLHEKDSE 1080
SGGGKD 1086 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0001772; C:immunological synapse; IEA:Compara.
 GO:0008305; C:integrin complex; NAS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0050798; P:activated T cell proliferation; IEA:Compara.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007157; P:heterophilic cell-cell adhesion; IMP:BHF-UCL.
 GO:0006954; P:inflammatory response; NAS:UniProtKB.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0007159; P:leukocyte cell-cell adhesion; IMP:BHF-UCL.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Compara.
 GO:0022409; P:positive regulation of cell-cell adhesion; IEA:Compara.
 GO:0042102; P:positive regulation of T cell proliferation; IEA:Compara.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0007165; P:signal transduction; NAS:UniProtKB.
 GO:0002291; P:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; IMP:BHF-UCL. 
Interpro
 IPR013517; FG-GAP.
 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha.
 IPR013649; Integrin_alpha-2.
 IPR018184; Integrin_alpha_C_CS.
 IPR002035; VWF_A. 
Pfam
 PF01839; FG-GAP
 PF00357; Integrin_alpha
 PF08441; Integrin_alpha2
 PF00092; VWA 
SMART
 SM00191; Int_alpha
 SM00327; VWA 
PROSITE
 PS51470; FG_GAP
 PS00242; INTEGRIN_ALPHA
 PS50234; VWFA 
PRINTS
 PR01185; INTEGRINA.