CPLM-021293

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-021293

UniProt Accession

AL8A1_HUMAN; Q9H2A2; B7Z521; O60793; Q24JS9; Q53GT3; Q5TI80

Genbank Protein ID

AF303134; AK290784; AK298325; AK222848; AL021939; AL445190; AL021939; AL445190; AL445190; AL021939; AL445190; AL021939; CH471051; CH471051; BC113862; BC114473

Genbank Nucleotide ID

AAG42417.1; BAF83473.1; BAH12757.1; BAD96568.1; CAI20305.1; CAI20305.1; CAI20306.1; CAI20306.1; CAI95158.1; CAI95158.1; CAI95159.1; CAI95159.1; EAW47985.1; EAW47986.1; AAI13863.1; AAI14474.1

Protein Name

Aldehyde dehydrogenase family 8 member A1

Protein Synonyms/Alias

Aldehyde dehydrogenase 12

Gene Name

ALDH8A1

Gene Synonyms/Alias

ALDH12

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
437	RVHRVAKKLQSGLVW	methylation	[1]

Reference

[1] Large-scale global identification of protein lysine methylation in vivo.
Cao XJ, Arnaudo AM, Garcia BA.
Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]

Functional Description

Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro).

Sequence Annotation

NP_BIND 209 215 NAD (Potential).
ACT_SITE 253 253 Proton acceptor (By similarity).
ACT_SITE 287 287 Nucleophile (By similarity).

Keyword

Alternative splicing; Complete proteome; Cytoplasm; NAD; Oxidoreductase; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

487 AA

Protein Sequence

MAGTNALLML ENFIDGKFLP CSSYIDSYDP STGEVYCRVP NSGKDEIEAA VKAAREAFPS 60
WSSRSPQERS RVLNQVADLL EQSLEEFAQA ESKDQGKTLA LARTMDIPRS VQNFRFFASS 120
SLHHTSECTQ MDHLGCMHYT VRAPVGVAGL ISPWNLPLYL LTWKIAPAMA AGNTVIAKPS 180
ELTSVTAWML CKLLDKAGVP PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIT 240
QLSAPHCKKL SLELGGKNPA IIFEDANLDE CIPATVRSSF ANQGEICLCT SRIFVQKSIY 300
SEFLKRFVEA TRKWKVGIPS DPLVSIGALI SKAHLEKVRS YVKRALAEGA QIWCGEGVDK 360
LSLPARNQAG YFMLPTVITD IKDESCCMTE EIFGPVTCVV PFDSEEEVIE RANNVKYGLA 420
ATVWSSNVGR VHRVAKKLQS GLVWTNCWLI RELNLPFGGM KSSGIGREGA KDSYDFFTEI 480
KTITVKH 487

Gene Ontology

GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005622; C:intracellular; IDA:UniProtKB.
GO:0001758; F:retinal dehydrogenase activity; IDA:UniProtKB.
GO:0042904; P:9-cis-retinoic acid biosynthetic process; IEA:Compara.
GO:0042574; P:retinal metabolic process; IDA:UniProtKB.
GO:0042573; P:retinoic acid metabolic process; IDA:UniProtKB.

Interpro

IPR016161; Ald_DH/histidinol_DH.
IPR016163; Ald_DH_C.
IPR016160; Ald_DH_CS.
IPR016162; Ald_DH_N.
IPR015590; Aldehyde_DH_dom.

Pfam

PF00171; Aldedh

SMART

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS
PS00687; ALDEHYDE_DEHYDR_GLU

PRINTS